Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

Use of Patient Health Records to Quantify Drug-Related Pro-arrhythmic Risk

Summary: There is an increasing expectation that computational approaches may supplement existing human decision-making. Frontloading of models for cardiac safety prediction is no exception to this trend, and ongoing regulatory initiatives propose use of high-throughput in vitro data combined with c...

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Bibliographic Details
Main Authors: Mark R. Davies, Michael Martinec, Robert Walls, Roman Schwarz, Gary R. Mirams, Ken Wang, Guido Steiner, Andy Surinach, Carlos Flores, Thierry Lavé, Thomas Singer, Liudmila Polonchuk
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Cell Reports Medicine
Subjects:
drug development
arrhythmia
cardiac safety
in silico models
real world data
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300975

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http://www.sciencedirect.com/science/article/pii/S2666379120300975

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