Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study)
BackgroundCarotid intima–media thickness (cIMT) is a noninvasive marker of cardiovascular risk. The cIMT may be increased in patients with harmonisation, but little is known regarding the functional form of the association between blood pressure (BP) and cIMT in hypertensive and nonhypertensive pers...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.116.003529 |
| _version_ | 1818328039776321536 |
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| author | João Pedro Ferreira Nicolas Girerd Erwan Bozec Jean Loup Machu Jean‐Marc Boivin Gérard M. London Faiez Zannad Patrick Rossignol |
| author_facet | João Pedro Ferreira Nicolas Girerd Erwan Bozec Jean Loup Machu Jean‐Marc Boivin Gérard M. London Faiez Zannad Patrick Rossignol |
| author_sort | João Pedro Ferreira |
| collection | DOAJ |
| description | BackgroundCarotid intima–media thickness (cIMT) is a noninvasive marker of cardiovascular risk. The cIMT may be increased in patients with harmonisation, but little is known regarding the functional form of the association between blood pressure (BP) and cIMT in hypertensive and nonhypertensive persons. We aimed to define the shape of the association between BP and cIMT. Methods and ResultsWe studied cIMT and ambulatory BP monitoring data from a single‐center, cross‐sectional, population‐based study involving 696 adult participants from the STANISLAS cohort, a familial longitudinal cohort from the Nancy region of France. Participants with a history of hypertension were more likely to have a cIMT >900 μm and had higher mean cIMT (both P<0.001). The risk of cIMT >900 μm increased linearly with higher 24‐hour and daytime systolic BP in participants both with and without history of hypertension. The relationship between systolic BP and the risk of cIMT >900 μm was not dependent on hypertension status (all P for interaction >0.10). In multivariable analysis adjusted on cardiovascular risk factors, each 5‐mm Hg increase in systolic BP was associated with an 8‐μm increase in cIMT (β=8.249 [95% CI 2.490–14.008], P=0.005). In contrast, the association between diastolic BP and cIMT was weaker and not significant. ConclusionsSystolic BP is linearly and continuously associated with higher cIMT in both hypertensive and nonhypertensive persons, suggesting a detrimental effect of BP on the vascular tree prior to overt hypertension. Similarly, it suggests a detrimental effect of BP at the higher end of the normal range in treated hypertensive patients. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT01391442. |
| first_indexed | 2024-12-13T12:25:50Z |
| format | Article |
| id | doaj.art-8ab5aab7c5ec4c73814999dab8e21247 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-13T12:25:50Z |
| publishDate | 2016-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-8ab5aab7c5ec4c73814999dab8e212472022-12-21T23:46:19ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-06-015610.1161/JAHA.116.003529Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study)João Pedro Ferreira0Nicolas Girerd1Erwan Bozec2Jean Loup Machu3Jean‐Marc Boivin4Gérard M. London5Faiez Zannad6Patrick Rossignol7INSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceF‐CRIN INI‐CRCT, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceINSERM, Centre d'Investigations Cliniques Plurithématique 1433, Université de Lorraine, CHRU de Nancy, Nancy, FranceBackgroundCarotid intima–media thickness (cIMT) is a noninvasive marker of cardiovascular risk. The cIMT may be increased in patients with harmonisation, but little is known regarding the functional form of the association between blood pressure (BP) and cIMT in hypertensive and nonhypertensive persons. We aimed to define the shape of the association between BP and cIMT. Methods and ResultsWe studied cIMT and ambulatory BP monitoring data from a single‐center, cross‐sectional, population‐based study involving 696 adult participants from the STANISLAS cohort, a familial longitudinal cohort from the Nancy region of France. Participants with a history of hypertension were more likely to have a cIMT >900 μm and had higher mean cIMT (both P<0.001). The risk of cIMT >900 μm increased linearly with higher 24‐hour and daytime systolic BP in participants both with and without history of hypertension. The relationship between systolic BP and the risk of cIMT >900 μm was not dependent on hypertension status (all P for interaction >0.10). In multivariable analysis adjusted on cardiovascular risk factors, each 5‐mm Hg increase in systolic BP was associated with an 8‐μm increase in cIMT (β=8.249 [95% CI 2.490–14.008], P=0.005). In contrast, the association between diastolic BP and cIMT was weaker and not significant. ConclusionsSystolic BP is linearly and continuously associated with higher cIMT in both hypertensive and nonhypertensive persons, suggesting a detrimental effect of BP on the vascular tree prior to overt hypertension. Similarly, it suggests a detrimental effect of BP at the higher end of the normal range in treated hypertensive patients. Clinical Trial RegistrationURL: https://www.clinicaltrials.gov/. Unique identifier: NCT01391442.https://www.ahajournals.org/doi/10.1161/JAHA.116.003529ambulatory blood pressure monitoringhypertensionintima–media thicknesslinear associations |
| spellingShingle | João Pedro Ferreira Nicolas Girerd Erwan Bozec Jean Loup Machu Jean‐Marc Boivin Gérard M. London Faiez Zannad Patrick Rossignol Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease ambulatory blood pressure monitoring hypertension intima–media thickness linear associations |
| title | Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) |
| title_full | Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) |
| title_fullStr | Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) |
| title_full_unstemmed | Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) |
| title_short | Intima–Media Thickness Is Linearly and Continuously Associated With Systolic Blood Pressure in a Population‐Based Cohort (STANISLAS Cohort Study) |
| title_sort | intima media thickness is linearly and continuously associated with systolic blood pressure in a population based cohort stanislas cohort study |
| topic | ambulatory blood pressure monitoring hypertension intima–media thickness linear associations |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.116.003529 |
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