Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome
Abstract Background The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. Methods This retrospective cross-sectional s...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-10-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12958-018-0419-x |
| _version_ | 1818578622763499520 |
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| author | Liangshan Mu Jiexue Pan Lili Yang Qianqian Chen Ya Chen Yili Teng Peiyu Wang Rong Tang Xuefeng Huang Xia Chen Haiyan Yang |
| author_facet | Liangshan Mu Jiexue Pan Lili Yang Qianqian Chen Ya Chen Yili Teng Peiyu Wang Rong Tang Xuefeng Huang Xia Chen Haiyan Yang |
| author_sort | Liangshan Mu |
| collection | DOAJ |
| description | Abstract Background The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. Methods This retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects. Results The serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS. Conclusions The serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS. |
| first_indexed | 2024-12-16T06:48:44Z |
| format | Article |
| id | doaj.art-8ab6ad274a0142009fd45ae677706cc5 |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-12-16T06:48:44Z |
| publishDate | 2018-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-8ab6ad274a0142009fd45ae677706cc52022-12-21T22:40:27ZengBMCReproductive Biology and Endocrinology1477-78272018-10-011611610.1186/s12958-018-0419-xAssociation between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndromeLiangshan Mu0Jiexue Pan1Lili Yang2Qianqian Chen3Ya Chen4Yili Teng5Peiyu Wang6Rong Tang7Xuefeng Huang8Xia Chen9Haiyan Yang10Reproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityRadiology Department, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityReproductive Medicine Center, The First Affiliated Hospital of Wenzhou Medical UniversityAbstract Background The prevalecne of hyperuricemia in polycystic ovary syndrome (PCOS) is still uncertain. We aimed to investigate the prevalence of hyperuricemia in PCOS and to determine the influence of reproductive hormones on uric acid concentration. Methods This retrospective cross-sectional study was performed at a large reproductive medicine center. Between March 2007 and October 2016, a total of 1,183 women with PCOS and 10,772 women without PCOS were included. PCOS was diagnosed according to the Rotterdam criteria. Anthropometric parameters, blood pressure, uric acid, reproductive hormones, glucose and lipids were measured in all subjects. Results The serum uric acid (SUA) level was higher in women with PCOS than in women without PCOS. The prevalence of hyperuricemia in women with PCOS (25.48%) was significantly higher than that in women without PCOS (8.74%). Analysis stratified for age and body mass index (BMI) showed that both the SUA level and the prevalence of hyperuricemia were higher in women with PCOS of different age and BMI groups than in women without PCOS. After adjusting for age, BMI and estimated glomerular filtration rate (eGFR), logistic regression analysis revealed that the luteinizing/follicle-stimulating hormone (LH/FSH) ratio (odds ratio (OR) = 1.20, 95% CI = 1.01–1.43) and testosterone level (OR = 1.56, 95% CI = 1.27–1.90) were positively associated with the prevalence of hyperuricemia in females with PCOS. Conclusions The serum uric acid (SUA) level and the prevalence of hyperuricemia markedly increased in women with PCOS. The testosterone level was positively associated with the SUA level and the prevalence of hyperuricemia in females with PCOS.http://link.springer.com/article/10.1186/s12958-018-0419-xPolycystic ovary syndromeUric acidSex hormonesHyperuricemia |
| spellingShingle | Liangshan Mu Jiexue Pan Lili Yang Qianqian Chen Ya Chen Yili Teng Peiyu Wang Rong Tang Xuefeng Huang Xia Chen Haiyan Yang Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome Reproductive Biology and Endocrinology Polycystic ovary syndrome Uric acid Sex hormones Hyperuricemia |
| title | Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| title_full | Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| title_fullStr | Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| title_full_unstemmed | Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| title_short | Association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| title_sort | association between the prevalence of hyperuricemia and reproductive hormones in polycystic ovary syndrome |
| topic | Polycystic ovary syndrome Uric acid Sex hormones Hyperuricemia |
| url | http://link.springer.com/article/10.1186/s12958-018-0419-x |
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