Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer
Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fif...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Nature Portfolio
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-93485-1 |
| _version_ | 1818840336538009600 |
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| author | Rachelle P. Mendoza Tahmineh Haidary Elmer Gabutan Ying Yin Zhou Zaheer Bukhari Courtney Connelly Wen-Ching Lee Yi-Chun Lee Raj Wadgaonkar Raag Agrawal M. A. Haseeb Raavi Gupta |
| author_facet | Rachelle P. Mendoza Tahmineh Haidary Elmer Gabutan Ying Yin Zhou Zaheer Bukhari Courtney Connelly Wen-Ching Lee Yi-Chun Lee Raj Wadgaonkar Raag Agrawal M. A. Haseeb Raavi Gupta |
| author_sort | Rachelle P. Mendoza |
| collection | DOAJ |
| description | Abstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fifty four of the 60 (90%) patients were Black and 36 (60%) were < 55 years of age. Of the 40 patients with typeable HPV genotypes, 10 (25%) had 16/18 HPV genotypes, 30 (75%) had one of the non-16/18 HPV genotypes, and 20 (50%) had one of the 7 genotypes (35, 39, 51, 53, 56, 59 and 68) that are not included in the nonavalent vaccine. Mixed HPV infections (≥ 2 types) were found in 11/40 (27.5%) patients. Patients infected with non-16/18 genotypes, including the most common genotype, HPV 35, had significantly shorter DFS and OS. PD-L1 (p = 0.003), MMR expression (p = 0.01), clinical stage (p = 0.048), histologic grade (p = 0.015) and mixed HPV infection (p = 0.026) were independent predictors of DFS. A remarkably high proportion of cervical cancer cells in our patients expressed PD-L1 which opens the possibility of the use of immune checkpoint inhibitors to treat these cancers. Exclusion of the common HPV genotypes from the vaccine exacerbates mortality from cervical cancer in underserved Black patients. |
| first_indexed | 2024-12-19T04:08:34Z |
| format | Article |
| id | doaj.art-8ab96b152efb45fb933267759e17be5a |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-19T04:08:34Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8ab96b152efb45fb933267759e17be5a2022-12-21T20:36:29ZengNature PortfolioScientific Reports2045-23222021-07-0111111410.1038/s41598-021-93485-1Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancerRachelle P. Mendoza0Tahmineh Haidary1Elmer Gabutan2Ying Yin Zhou3Zaheer Bukhari4Courtney Connelly5Wen-Ching Lee6Yi-Chun Lee7Raj Wadgaonkar8Raag Agrawal9M. A. Haseeb10Raavi Gupta11Department of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Medicine, State University of New York, Downstate Health Sciences UniversityDepartment of Obstetrics and Gynecology, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Obstetrics and Gynecology, State University of New York, Downstate Health Sciences UniversityDepartment of Obstetrics and Gynecology, State University of New York, Downstate Health Sciences UniversityDepartment of Medicine, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityDepartment of Pathology, State University of New York, Downstate Health Sciences UniversityAbstract We studied the incidence of HPV genotypes in mostly Black women with cervical carcinoma and correlated histopathologic tumor characteristics, immune markers and clinical data with survival. Disease-free survival (DFS) and overall survival (OS) were recorded for 60 months post-diagnosis. Fifty four of the 60 (90%) patients were Black and 36 (60%) were < 55 years of age. Of the 40 patients with typeable HPV genotypes, 10 (25%) had 16/18 HPV genotypes, 30 (75%) had one of the non-16/18 HPV genotypes, and 20 (50%) had one of the 7 genotypes (35, 39, 51, 53, 56, 59 and 68) that are not included in the nonavalent vaccine. Mixed HPV infections (≥ 2 types) were found in 11/40 (27.5%) patients. Patients infected with non-16/18 genotypes, including the most common genotype, HPV 35, had significantly shorter DFS and OS. PD-L1 (p = 0.003), MMR expression (p = 0.01), clinical stage (p = 0.048), histologic grade (p = 0.015) and mixed HPV infection (p = 0.026) were independent predictors of DFS. A remarkably high proportion of cervical cancer cells in our patients expressed PD-L1 which opens the possibility of the use of immune checkpoint inhibitors to treat these cancers. Exclusion of the common HPV genotypes from the vaccine exacerbates mortality from cervical cancer in underserved Black patients.https://doi.org/10.1038/s41598-021-93485-1 |
| spellingShingle | Rachelle P. Mendoza Tahmineh Haidary Elmer Gabutan Ying Yin Zhou Zaheer Bukhari Courtney Connelly Wen-Ching Lee Yi-Chun Lee Raj Wadgaonkar Raag Agrawal M. A. Haseeb Raavi Gupta Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer Scientific Reports |
| title | Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer |
| title_full | Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer |
| title_fullStr | Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer |
| title_full_unstemmed | Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer |
| title_short | Mixed and nonvaccine high risk HPV types are associated with higher mortality in Black women with cervical cancer |
| title_sort | mixed and nonvaccine high risk hpv types are associated with higher mortality in black women with cervical cancer |
| url | https://doi.org/10.1038/s41598-021-93485-1 |
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