Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia
Immediate hypersensitivity reactions (IHR) are rare but potentially serious adverse events following immunization (AEFI). Surveillance of Adverse Events following Vaccination in the Community (SAEFVIC) is an enhanced passive surveillance system that collects, analyses and reports information about A...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-08-01
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| Series: | Human Vaccines & Immunotherapeutics |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21645515.2018.1460293 |
| _version_ | 1797677485162233856 |
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| author | C.-M. Baxter H. J. Clothier K. P. Perrett |
| author_facet | C.-M. Baxter H. J. Clothier K. P. Perrett |
| author_sort | C.-M. Baxter |
| collection | DOAJ |
| description | Immediate hypersensitivity reactions (IHR) are rare but potentially serious adverse events following immunization (AEFI). Surveillance of Adverse Events following Vaccination in the Community (SAEFVIC) is an enhanced passive surveillance system that collects, analyses and reports information about AEFI in Victoria, Australia. We describe the incidence, timing and type of potential IHR following vaccination in preschool children reported over an 8-year period. A total of 2110 AEFI were reported in 1620 children, of which 23.5% (496) were classified as potential IHR. Of these, 37.1% (184) were suspected to be IgE-mediated, (including anaphylaxis, angioedema and/or urticaria) and 83.5% (414) occurred within 15 minutes of vaccination. The incidence of potential IHR was 5.4 per 100,000 doses, with that of suspected IgE-mediated IHR being 2.0 per 100,000 doses. The incidence of anaphylaxis was extremely low (0.13 per 100,000 doses) and is consistent with other published studies. Potential IHR following immunization should be reported to appropriate local pharmacovigilance systems and patients reviewed by specialists able to evaluate, investigate and manage future vaccinations. |
| first_indexed | 2024-03-11T22:45:49Z |
| format | Article |
| id | doaj.art-8ab9e64cc26244318e54f3ae481419a0 |
| institution | Directory Open Access Journal |
| issn | 2164-5515 2164-554X |
| language | English |
| last_indexed | 2024-03-11T22:45:49Z |
| publishDate | 2018-08-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Human Vaccines & Immunotherapeutics |
| spelling | doaj.art-8ab9e64cc26244318e54f3ae481419a02023-09-22T08:38:21ZengTaylor & Francis GroupHuman Vaccines & Immunotherapeutics2164-55152164-554X2018-08-011482088209210.1080/21645515.2018.14602931460293Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, AustraliaC.-M. Baxter0H. J. Clothier1K. P. Perrett2The Royal Children's HospitalSurveillance of Adverse Events following Immunisation in Victoria (SAEFVIC), Murdoch Children's Research InstituteSchool of Population & Global Health, University of MelbourneImmediate hypersensitivity reactions (IHR) are rare but potentially serious adverse events following immunization (AEFI). Surveillance of Adverse Events following Vaccination in the Community (SAEFVIC) is an enhanced passive surveillance system that collects, analyses and reports information about AEFI in Victoria, Australia. We describe the incidence, timing and type of potential IHR following vaccination in preschool children reported over an 8-year period. A total of 2110 AEFI were reported in 1620 children, of which 23.5% (496) were classified as potential IHR. Of these, 37.1% (184) were suspected to be IgE-mediated, (including anaphylaxis, angioedema and/or urticaria) and 83.5% (414) occurred within 15 minutes of vaccination. The incidence of potential IHR was 5.4 per 100,000 doses, with that of suspected IgE-mediated IHR being 2.0 per 100,000 doses. The incidence of anaphylaxis was extremely low (0.13 per 100,000 doses) and is consistent with other published studies. Potential IHR following immunization should be reported to appropriate local pharmacovigilance systems and patients reviewed by specialists able to evaluate, investigate and manage future vaccinations.http://dx.doi.org/10.1080/21645515.2018.1460293vaccine hypersensitivityvaccine allergyadverse events following immunization (aefi) |
| spellingShingle | C.-M. Baxter H. J. Clothier K. P. Perrett Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia Human Vaccines & Immunotherapeutics vaccine hypersensitivity vaccine allergy adverse events following immunization (aefi) |
| title | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
| title_full | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
| title_fullStr | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
| title_full_unstemmed | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
| title_short | Potential immediate hypersensitivity reactions following immunization in preschool aged children in Victoria, Australia |
| title_sort | potential immediate hypersensitivity reactions following immunization in preschool aged children in victoria australia |
| topic | vaccine hypersensitivity vaccine allergy adverse events following immunization (aefi) |
| url | http://dx.doi.org/10.1080/21645515.2018.1460293 |
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