Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.

Toward new therapeutics for skin and soft tissue infections: propargyl-linked antifolates are potent inhibitors of MRSA and Streptococcus pyogenes.

Hospital- and community-acquired, complicated skin and soft tissue infections, often attributed to Staphylococcus aureus and Streptococcus pyogenes, present a significant health burden that is associated with increased health care costs and mortality. As these two species are difficult to discern on...

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Bibliographic Details
Main Authors: Kishore Viswanathan, Kathleen M Frey, Eric W Scocchera, Brooke D Martin, P Whitney Swain Iii, Jeremy B Alverson, Nigel D Priestley, Amy C Anderson, Dennis L Wright
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3274548?pdf=render

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http://europepmc.org/articles/PMC3274548?pdf=render

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