Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial
Aim: This retrospective cohort study aimed to evaluate the prognostic implications of the distinct atrial fibrillation (AF) temporal patterns: first diagnosed, paroxysmal, and persistent or permanent AF. Methods: In this post hoc analysis of the MISOAC-AF trial (NCT02941978), a total of 1052 patient...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2022-01-01
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| Series: | Journal of Cardiovascular Pharmacology and Therapeutics |
| Online Access: | https://doi.org/10.1177/10742484211069422 |
| _version_ | 1811330215927873536 |
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| author | Amalia Baroutidou MD Anastasios Kartas MD, MSc Athanasios Samaras MD Andreas S. Papazoglou MD Eleni Vrana MD Dimitrios V. Moysidis MD Evangelos Akrivos MSc Anastasios Papanastasiou MD, MSc Ioannis Vouloagkas MD Michail Botis MD Evangelos Liampas MD Artemios G. Karagiannidis MD Efstratios Karagiannidis MD, PhD Georgios Efthimiadis MD, PhD Haralambos Karvounis MD, PhD Apostolos Tzikas MD, PhD George Giannakoulas MD, PhD |
| author_facet | Amalia Baroutidou MD Anastasios Kartas MD, MSc Athanasios Samaras MD Andreas S. Papazoglou MD Eleni Vrana MD Dimitrios V. Moysidis MD Evangelos Akrivos MSc Anastasios Papanastasiou MD, MSc Ioannis Vouloagkas MD Michail Botis MD Evangelos Liampas MD Artemios G. Karagiannidis MD Efstratios Karagiannidis MD, PhD Georgios Efthimiadis MD, PhD Haralambos Karvounis MD, PhD Apostolos Tzikas MD, PhD George Giannakoulas MD, PhD |
| author_sort | Amalia Baroutidou MD |
| collection | DOAJ |
| description | Aim: This retrospective cohort study aimed to evaluate the prognostic implications of the distinct atrial fibrillation (AF) temporal patterns: first diagnosed, paroxysmal, and persistent or permanent AF. Methods: In this post hoc analysis of the MISOAC-AF trial (NCT02941978), a total of 1052 patients with AF (median age 76 years), discharged from the cardiology ward between 2015 and 2018, were analyzed. Kaplan-Meier and Cox-regression analyses were performed to compare the primary outcome of all-cause mortality, the secondary outcomes of stroke, major bleeding and the composite outcome of cardiovascular (CV) mortality or hospitalization among AF patterns. Results: Of patients, 121 (11.2%) had first diagnosed, 356 (33%) paroxysmal, and 575 (53.2%) persistent or permanent AF. During a median follow-up of 31 months (interquartile range 10 to 52 months), 37.3% of patients died. Compared with paroxysmal AF, patients with persistent or permanent AF had higher mortality rates (adjusted hazard ratio (aHR), 1.37; 95% confidence interval [CI], 1.08-1.74, P = .009), but similar CV mortality or hospitalization rates (aHR, 1.09; 95% CI, 0.91-1.31, P = .35). Compared with first diagnosed AF, patients with persistent or permanent AF had similar mortality (aHR, 1.26; 95% CI, 0.87-1.82, P = .24), but higher CV mortality or hospitalization rates (aHR, 1.35; 95% CI, 1.01-1.8, P = .04). Stroke and major bleeding events did not differ across AF patterns (all P > .05). Conclusions: In conclusion, in recently hospitalized patients with comorbid AF, the presence of persistent or permanent AF was associated with a higher incidence of mortality and morbidity compared with paroxysmal and first diagnosed AF. |
| first_indexed | 2024-04-13T15:57:28Z |
| format | Article |
| id | doaj.art-8abc70c7f0884a47838cd210bfbe6f95 |
| institution | Directory Open Access Journal |
| issn | 1940-4034 |
| language | English |
| last_indexed | 2024-04-13T15:57:28Z |
| publishDate | 2022-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Cardiovascular Pharmacology and Therapeutics |
| spelling | doaj.art-8abc70c7f0884a47838cd210bfbe6f952022-12-22T02:40:38ZengSAGE PublishingJournal of Cardiovascular Pharmacology and Therapeutics1940-40342022-01-012710.1177/10742484211069422Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF TrialAmalia Baroutidou MD0Anastasios Kartas MD, MSc1Athanasios Samaras MD2Andreas S. Papazoglou MD3Eleni Vrana MD4Dimitrios V. Moysidis MD5Evangelos Akrivos MSc6Anastasios Papanastasiou MD, MSc7Ioannis Vouloagkas MD8Michail Botis MD9Evangelos Liampas MD10Artemios G. Karagiannidis MD11Efstratios Karagiannidis MD, PhD12Georgios Efthimiadis MD, PhD13Haralambos Karvounis MD, PhD14Apostolos Tzikas MD, PhD15George Giannakoulas MD, PhD16 First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece Laboratory of Computing, , Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, Greece , Thessaloniki, Greece First Department of Cardiology, , Thessaloniki, GreeceAim: This retrospective cohort study aimed to evaluate the prognostic implications of the distinct atrial fibrillation (AF) temporal patterns: first diagnosed, paroxysmal, and persistent or permanent AF. Methods: In this post hoc analysis of the MISOAC-AF trial (NCT02941978), a total of 1052 patients with AF (median age 76 years), discharged from the cardiology ward between 2015 and 2018, were analyzed. Kaplan-Meier and Cox-regression analyses were performed to compare the primary outcome of all-cause mortality, the secondary outcomes of stroke, major bleeding and the composite outcome of cardiovascular (CV) mortality or hospitalization among AF patterns. Results: Of patients, 121 (11.2%) had first diagnosed, 356 (33%) paroxysmal, and 575 (53.2%) persistent or permanent AF. During a median follow-up of 31 months (interquartile range 10 to 52 months), 37.3% of patients died. Compared with paroxysmal AF, patients with persistent or permanent AF had higher mortality rates (adjusted hazard ratio (aHR), 1.37; 95% confidence interval [CI], 1.08-1.74, P = .009), but similar CV mortality or hospitalization rates (aHR, 1.09; 95% CI, 0.91-1.31, P = .35). Compared with first diagnosed AF, patients with persistent or permanent AF had similar mortality (aHR, 1.26; 95% CI, 0.87-1.82, P = .24), but higher CV mortality or hospitalization rates (aHR, 1.35; 95% CI, 1.01-1.8, P = .04). Stroke and major bleeding events did not differ across AF patterns (all P > .05). Conclusions: In conclusion, in recently hospitalized patients with comorbid AF, the presence of persistent or permanent AF was associated with a higher incidence of mortality and morbidity compared with paroxysmal and first diagnosed AF.https://doi.org/10.1177/10742484211069422 |
| spellingShingle | Amalia Baroutidou MD Anastasios Kartas MD, MSc Athanasios Samaras MD Andreas S. Papazoglou MD Eleni Vrana MD Dimitrios V. Moysidis MD Evangelos Akrivos MSc Anastasios Papanastasiou MD, MSc Ioannis Vouloagkas MD Michail Botis MD Evangelos Liampas MD Artemios G. Karagiannidis MD Efstratios Karagiannidis MD, PhD Georgios Efthimiadis MD, PhD Haralambos Karvounis MD, PhD Apostolos Tzikas MD, PhD George Giannakoulas MD, PhD Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial Journal of Cardiovascular Pharmacology and Therapeutics |
| title | Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial |
| title_full | Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial |
| title_fullStr | Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial |
| title_full_unstemmed | Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial |
| title_short | Associations of Atrial Fibrillation Patterns With Mortality and Cardiovascular Events: Implications of the MISOAC-AF Trial |
| title_sort | associations of atrial fibrillation patterns with mortality and cardiovascular events implications of the misoac af trial |
| url | https://doi.org/10.1177/10742484211069422 |
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