Discovery of Pathologic GPCR Aggregation
The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. This feature was considered to distinguish GP...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmed.2019.00009/full |
| _version_ | 1811232254477729792 |
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| author | Ursula Quitterer Ursula Quitterer Said AbdAlla |
| author_facet | Ursula Quitterer Ursula Quitterer Said AbdAlla |
| author_sort | Ursula Quitterer |
| collection | DOAJ |
| description | The family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. This feature was considered to distinguish GPCRs from other membrane receptors such as receptor tyrosine kinases or cytokine receptors, which signal from dimeric receptor complexes. But during the last two decades it was increasingly recognized that GPCRs can undergo aggregation to form dimers and higher order oligomers, resulting in homomeric and/or heteromeric protein complexes with different stoichiometries. Moreover, this protein complex formation could modify GPCR signaling and function. We contributed to this paradigm shift in GPCR pharmacology by the discovery of the first pathologic GPCR aggregation, which is the protein complex formation between the angiotensin II AT1 receptor and the bradykinin B2 receptor. Increased AT1-B2 heteromerization accounts for the angiotensin II hypersensitivity of pregnant women with preeclampsia hypertension. Since the discovery of AT1-B2, other pathologic GPCR aggregates were found, which contribute to atherosclerosis, neurodegeneration and Alzheimer's disease. As a result of our findings, pathologic GPCR aggregation appears as an independent and disease-specific process, which is increasingly considered as a novel target for pharmacologic intervention. |
| first_indexed | 2024-04-12T11:00:23Z |
| format | Article |
| id | doaj.art-8abc9624a0ff480e8bb60fef55ae9f0f |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-12T11:00:23Z |
| publishDate | 2019-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-8abc9624a0ff480e8bb60fef55ae9f0f2022-12-22T03:35:59ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2019-01-01610.3389/fmed.2019.00009440696Discovery of Pathologic GPCR AggregationUrsula Quitterer0Ursula Quitterer1Said AbdAlla2Molecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, SwitzerlandDepartment of Medicine, Institute of Pharmacology and Toxicology, University of Zurich, Zurich, SwitzerlandMolecular Pharmacology, Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, SwitzerlandThe family of G-protein-coupled receptors (GPCRs) is one of the most important drug targets. Mechanisms underlying GPCR activation and signaling are therefore of great pharmacologic interest. It was long thought that GPCRs exist and function as monomers. This feature was considered to distinguish GPCRs from other membrane receptors such as receptor tyrosine kinases or cytokine receptors, which signal from dimeric receptor complexes. But during the last two decades it was increasingly recognized that GPCRs can undergo aggregation to form dimers and higher order oligomers, resulting in homomeric and/or heteromeric protein complexes with different stoichiometries. Moreover, this protein complex formation could modify GPCR signaling and function. We contributed to this paradigm shift in GPCR pharmacology by the discovery of the first pathologic GPCR aggregation, which is the protein complex formation between the angiotensin II AT1 receptor and the bradykinin B2 receptor. Increased AT1-B2 heteromerization accounts for the angiotensin II hypersensitivity of pregnant women with preeclampsia hypertension. Since the discovery of AT1-B2, other pathologic GPCR aggregates were found, which contribute to atherosclerosis, neurodegeneration and Alzheimer's disease. As a result of our findings, pathologic GPCR aggregation appears as an independent and disease-specific process, which is increasingly considered as a novel target for pharmacologic intervention.https://www.frontiersin.org/article/10.3389/fmed.2019.00009/fullG-protein-coupled receptoroligomerizationpreeclampsiaatherosclerosisAlzheimer's diseaseneurodegeneration |
| spellingShingle | Ursula Quitterer Ursula Quitterer Said AbdAlla Discovery of Pathologic GPCR Aggregation Frontiers in Medicine G-protein-coupled receptor oligomerization preeclampsia atherosclerosis Alzheimer's disease neurodegeneration |
| title | Discovery of Pathologic GPCR Aggregation |
| title_full | Discovery of Pathologic GPCR Aggregation |
| title_fullStr | Discovery of Pathologic GPCR Aggregation |
| title_full_unstemmed | Discovery of Pathologic GPCR Aggregation |
| title_short | Discovery of Pathologic GPCR Aggregation |
| title_sort | discovery of pathologic gpcr aggregation |
| topic | G-protein-coupled receptor oligomerization preeclampsia atherosclerosis Alzheimer's disease neurodegeneration |
| url | https://www.frontiersin.org/article/10.3389/fmed.2019.00009/full |
| work_keys_str_mv | AT ursulaquitterer discoveryofpathologicgpcraggregation AT ursulaquitterer discoveryofpathologicgpcraggregation AT saidabdalla discoveryofpathologicgpcraggregation |