Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide
In this paper, a rapid and efficient method for the preparation of scopolamine hydrobromide with high purity was established, named as magnetic field-induced crystallization. Based on the difference in solubility between scopolamine and scopolamine hydrobromide, salifying crystallization was selecte...
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MDPI AG
2023-09-01
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| Online Access: | https://www.mdpi.com/2297-8739/10/9/504 |
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| author | Zeyu Wu Pengpeng Chen Huixi Bian An Zhou Kun Xu Wencheng Zhang |
| author_facet | Zeyu Wu Pengpeng Chen Huixi Bian An Zhou Kun Xu Wencheng Zhang |
| author_sort | Zeyu Wu |
| collection | DOAJ |
| description | In this paper, a rapid and efficient method for the preparation of scopolamine hydrobromide with high purity was established, named as magnetic field-induced crystallization. Based on the difference in solubility between scopolamine and scopolamine hydrobromide, salifying crystallization was selected and then treated with the synergistic effect of magnetic field to achieve the goal of purifying scopolamine. The influence of crystallization solvents and magnetic field intensity on the crystallization process of scopolamine hydrobromide, as well as the impact of magnetic field on the crystal growth direction, were investigated. The results revealed that treatment under magnetic field led to a shortened induction time (25.64–75.46%), an increased purity of crystals (0.95–2.92%), and an enhanced recovery rate (4.51–10.78%). Furthermore, it was also discovered that magnetic field could destroy hydrogen bonds within the solution, and change the physical properties of the mother liquid, so as to promote the nucleation formation and crystal growth. These findings suggested that external magnetic field could be a promising method for scopolamine preparation. |
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| id | doaj.art-8abd20b049d9448981e1c0f870cc1eae |
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| language | English |
| last_indexed | 2024-03-10T22:00:33Z |
| publishDate | 2023-09-01 |
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| spelling | doaj.art-8abd20b049d9448981e1c0f870cc1eae2023-11-19T12:58:04ZengMDPI AGSeparations2297-87392023-09-0110950410.3390/separations10090504Application of Magnetic Field to Accelerate the Crystallization of Scopolamine HydrobromideZeyu Wu0Pengpeng Chen1Huixi Bian2An Zhou3Kun Xu4Wencheng Zhang5Engineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, ChinaEngineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, ChinaEngineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, ChinaThe Experimental Research Center, Anhui University of Chinese Medicine, Hefei 230038, ChinaAnhui Dexinjia Biopharm Co., Ltd., Fuyang 236636, ChinaEngineering Research Center of Bio-Process of Ministry of Education, School of Food and Biological Engineering, Hefei University of Technology, Hefei 230601, ChinaIn this paper, a rapid and efficient method for the preparation of scopolamine hydrobromide with high purity was established, named as magnetic field-induced crystallization. Based on the difference in solubility between scopolamine and scopolamine hydrobromide, salifying crystallization was selected and then treated with the synergistic effect of magnetic field to achieve the goal of purifying scopolamine. The influence of crystallization solvents and magnetic field intensity on the crystallization process of scopolamine hydrobromide, as well as the impact of magnetic field on the crystal growth direction, were investigated. The results revealed that treatment under magnetic field led to a shortened induction time (25.64–75.46%), an increased purity of crystals (0.95–2.92%), and an enhanced recovery rate (4.51–10.78%). Furthermore, it was also discovered that magnetic field could destroy hydrogen bonds within the solution, and change the physical properties of the mother liquid, so as to promote the nucleation formation and crystal growth. These findings suggested that external magnetic field could be a promising method for scopolamine preparation.https://www.mdpi.com/2297-8739/10/9/504scopolaminecrystallizationmagnetic fieldphysical propertieshydrogen bond |
| spellingShingle | Zeyu Wu Pengpeng Chen Huixi Bian An Zhou Kun Xu Wencheng Zhang Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide Separations scopolamine crystallization magnetic field physical properties hydrogen bond |
| title | Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide |
| title_full | Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide |
| title_fullStr | Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide |
| title_full_unstemmed | Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide |
| title_short | Application of Magnetic Field to Accelerate the Crystallization of Scopolamine Hydrobromide |
| title_sort | application of magnetic field to accelerate the crystallization of scopolamine hydrobromide |
| topic | scopolamine crystallization magnetic field physical properties hydrogen bond |
| url | https://www.mdpi.com/2297-8739/10/9/504 |
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