Effect and Mechanism of siRNAs Targeting IL-1β/TNF-α Combined with BMSCs Transplantation in Ameliorating Rheumatoid Arthritis in Rats

Effect and Mechanism of siRNAs Targeting IL-1β/TNF-α Combined with BMSCs Transplantation in Ameliorating Rheumatoid Arthritis in Rats

Background: Rheumatoid arthritis (RA) is an autoimmune disease. Bone marrow mesenchymal stem cells (BMSCs) have multilineage differentiation and anti-inflammatory potential, and small interfering RNAs (siRNAs) can inhibit the target gene expression, which make them suitable for ameliorating RA. The...

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Bibliographic Details
Main Authors: Shifeng Pan, Lijun Wang, Bingxing Wu, Hua Xing
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Veterinary Sciences
Subjects:
siRNAs targeting IL-1β/TNF-α
bone marrow mesenchymal stem cells
rheumatoid arthritis
NF-κB signaling pathway
rats
Online Access:https://www.mdpi.com/2306-7381/9/10/531

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