Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma
Abstract We describe the potential utility of Amide Proton Transfer weighted (APTw) Magnetic Resonance Imaging and arterial spin labeling (ASL) in characterizing pilocytic astrocytoma (PA), a type of brain tumor that can be challenging to accurately diagnose and treat. The study included 50 patients...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-43235-2 |
| _version_ | 1797577053843750912 |
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| author | Adhithyan Rajendran Chidambaranathan Natesan Prashanth Jawahar Sushama Patil Srinivas Chilukuri Siddhartha Ghosh Roopesh Kumar Rakesh Jalali |
| author_facet | Adhithyan Rajendran Chidambaranathan Natesan Prashanth Jawahar Sushama Patil Srinivas Chilukuri Siddhartha Ghosh Roopesh Kumar Rakesh Jalali |
| author_sort | Adhithyan Rajendran |
| collection | DOAJ |
| description | Abstract We describe the potential utility of Amide Proton Transfer weighted (APTw) Magnetic Resonance Imaging and arterial spin labeling (ASL) in characterizing pilocytic astrocytoma (PA), a type of brain tumor that can be challenging to accurately diagnose and treat. The study included 50 patients with solid or predominantly solid intra-cranial and intra-axial tumors, with 25 patients diagnosed with PA and 25 patients diagnosed with other types of tumors. The study found that the APTw imaging-arterial spin labeling (ASL) mismatch is a new imaging biomarker that could be used to differentiate PA from other types of tumors with a high degree of sensitivity and specificity. The results suggest that APTw imaging and ASL may be useful in characterizing PA, potentially improving diagnosis and treatment planning for this type of brain tumor. |
| first_indexed | 2024-03-10T22:03:28Z |
| format | Article |
| id | doaj.art-8abfb69bac5f4e688302abfa272a529e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-10T22:03:28Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8abfb69bac5f4e688302abfa272a529e2023-11-19T12:53:22ZengNature PortfolioScientific Reports2045-23222023-09-0113111110.1038/s41598-023-43235-2Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytomaAdhithyan Rajendran0Chidambaranathan Natesan1Prashanth Jawahar2Sushama Patil3Srinivas Chilukuri4Siddhartha Ghosh5Roopesh Kumar6Rakesh Jalali7Apollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreApollo Proton Cancer CentreAbstract We describe the potential utility of Amide Proton Transfer weighted (APTw) Magnetic Resonance Imaging and arterial spin labeling (ASL) in characterizing pilocytic astrocytoma (PA), a type of brain tumor that can be challenging to accurately diagnose and treat. The study included 50 patients with solid or predominantly solid intra-cranial and intra-axial tumors, with 25 patients diagnosed with PA and 25 patients diagnosed with other types of tumors. The study found that the APTw imaging-arterial spin labeling (ASL) mismatch is a new imaging biomarker that could be used to differentiate PA from other types of tumors with a high degree of sensitivity and specificity. The results suggest that APTw imaging and ASL may be useful in characterizing PA, potentially improving diagnosis and treatment planning for this type of brain tumor.https://doi.org/10.1038/s41598-023-43235-2 |
| spellingShingle | Adhithyan Rajendran Chidambaranathan Natesan Prashanth Jawahar Sushama Patil Srinivas Chilukuri Siddhartha Ghosh Roopesh Kumar Rakesh Jalali Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma Scientific Reports |
| title | Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma |
| title_full | Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma |
| title_fullStr | Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma |
| title_full_unstemmed | Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma |
| title_short | Amide proton transfer imaging-arterial spin labeling mismatch: a new imaging biomarker for pilocytic astrocytoma |
| title_sort | amide proton transfer imaging arterial spin labeling mismatch a new imaging biomarker for pilocytic astrocytoma |
| url | https://doi.org/10.1038/s41598-023-43235-2 |
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