Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy
Darier disease is a rare autosomal dominant disease characterized by abnormal keratinization of the epidermis, mucosa, and nails. Acitretin, an aromatic form of tretinoin, is widely prescribed in the treatment of Darier disease. However, significant adverse effects can occur and there have been repo...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2014-03-01
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| Series: | Dermatologica Sinica |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1027811713000207 |
| _version_ | 1818142475778260992 |
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| author | Yi-Hao Wang Dino Tsai |
| author_facet | Yi-Hao Wang Dino Tsai |
| author_sort | Yi-Hao Wang |
| collection | DOAJ |
| description | Darier disease is a rare autosomal dominant disease characterized by abnormal keratinization of the epidermis, mucosa, and nails. Acitretin, an aromatic form of tretinoin, is widely prescribed in the treatment of Darier disease. However, significant adverse effects can occur and there have been reports associating intestinal inflammation with retinoid therapy. We report the case of a 58-year-old man who developed a small intestine perforation after 2 years of acitretin treatment. Having excluded other common causes, we suspected that the small intestine perforation could be the result of severe inflammation of small intestine due to the long-term use of acitretin. Given the significance of this potential morbidity, it would seem prudent to monitor acitretin treatment for treating Darier disease by paying more attention to clinical symptoms such as abdominal pain or bloody stool. |
| first_indexed | 2024-12-11T11:16:22Z |
| format | Article |
| id | doaj.art-8ac0d57b9ec548f89eb590ada42ca200 |
| institution | Directory Open Access Journal |
| issn | 1027-8117 |
| language | English |
| last_indexed | 2024-12-11T11:16:22Z |
| publishDate | 2014-03-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Dermatologica Sinica |
| spelling | doaj.art-8ac0d57b9ec548f89eb590ada42ca2002022-12-22T01:09:20ZengWolters Kluwer Medknow PublicationsDermatologica Sinica1027-81172014-03-01321394210.1016/j.dsi.2013.02.002Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapyYi-Hao WangDino TsaiDarier disease is a rare autosomal dominant disease characterized by abnormal keratinization of the epidermis, mucosa, and nails. Acitretin, an aromatic form of tretinoin, is widely prescribed in the treatment of Darier disease. However, significant adverse effects can occur and there have been reports associating intestinal inflammation with retinoid therapy. We report the case of a 58-year-old man who developed a small intestine perforation after 2 years of acitretin treatment. Having excluded other common causes, we suspected that the small intestine perforation could be the result of severe inflammation of small intestine due to the long-term use of acitretin. Given the significance of this potential morbidity, it would seem prudent to monitor acitretin treatment for treating Darier disease by paying more attention to clinical symptoms such as abdominal pain or bloody stool.http://www.sciencedirect.com/science/article/pii/S1027811713000207small intestine perforationacitretinDarier disease |
| spellingShingle | Yi-Hao Wang Dino Tsai Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy Dermatologica Sinica small intestine perforation acitretin Darier disease |
| title | Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy |
| title_full | Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy |
| title_fullStr | Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy |
| title_full_unstemmed | Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy |
| title_short | Small intestine perforation in a 58-year-old man with Darier disease after 25 months of oral acitretin therapy |
| title_sort | small intestine perforation in a 58 year old man with darier disease after 25 months of oral acitretin therapy |
| topic | small intestine perforation acitretin Darier disease |
| url | http://www.sciencedirect.com/science/article/pii/S1027811713000207 |
| work_keys_str_mv | AT yihaowang smallintestineperforationina58yearoldmanwithdarierdiseaseafter25monthsoforalacitretintherapy AT dinotsai smallintestineperforationina58yearoldmanwithdarierdiseaseafter25monthsoforalacitretintherapy |