Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

Developmental Origin of Oligodendrocyte Lineage Cells Determines Response to Demyelination and Susceptibility to Age-Associated Functional Decline

Oligodendrocyte progenitors (OPs) arise from distinct ventral and dorsal domains within the ventricular germinal zones of the embryonic CNS. The functional significance, if any, of these different populations is not known. Using dual-color reporter mice to distinguish ventrally and dorsally derived...

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Bibliographic Details
Main Authors: Abbe H. Crawford, Richa B. Tripathi, William D. Richardson, Robin J.M. Franklin
Format: Article
Language:English
Published: Elsevier 2016-04-01
Series:Cell Reports
Subjects:
myelin
oligodendrocyte
glial diversity
remyelination
oligodendrocyte progenitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716303588

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