Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults

Respective influence of beta-amyloid and APOE ε4 genotype on medial temporal lobe subregions in cognitively unimpaired older adults

Medial temporal lobe (MTL) subregions are differentially affected in Alzheimer's disease (AD), with a specific involvement of the entorhinal cortex (ERC), perirhinal cortex and hippocampal cornu ammonis (CA)1. While amyloid (Aβ) and APOEε4 are respectively the first molecular change and the mai...

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Bibliographic Details
Main Authors: Robin de Flores, Solène Demeilliez-Servouin, Elizabeth Kuhn, Léa Chauveau, Brigitte Landeau, Nicolas Delcroix, Julie Gonneaud, Denis Vivien, Gaël Chételat
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
Medial temporal lobe
Hippocampal subfields
Amyloid
APOE
Alzheimer's disease
Age
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001419

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