Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Scaffold Searching of FDA and EMA-Approved Drugs Identifies Lead Candidates for Drug Repurposing in Alzheimer’s Disease

Clinical trials of novel therapeutics for Alzheimer’s Disease (AD) have consumed a significant amount of time and resources with largely negative results. Repurposing drugs already approved by the Food and Drug Administration (FDA), European Medicines Agency (EMA), or Worldwide for another indicatio...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Sergey Shityakov, Ekaterina V. Skorb, Carola Y. Förster, Thomas Dandekar
Format: Artikel
Sprache:English
Veröffentlicht: Frontiers Media S.A. 2021-10-01
Schriftenreihe:Frontiers in Chemistry
Schlagworte:
scaffold search
approved drugs
drug repurposing
alzheimer's disease
chemical similarity
molecular modeling
Online Zugang:https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

Online

https://www.frontiersin.org/articles/10.3389/fchem.2021.736509/full

Ähnliche Einträge