Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT
Background: This study aims to establish a reference for the superior–inferior hemisphere asymmetry in thickness values for all macular layers for the posterior pole algorithm (PPA) available for the Spectralis SD-OCT device. Methods: We examined 300 eyes of 300 healthy Caucasian volunteers aged 18–...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/24/7609 |
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| author | Ana Palazon-Cabanes Begoña Palazon-Cabanes Jose Javier Garcia-Medina Aurora Alvarez-Sarrion Monica del-Rio-Vellosillo |
| author_facet | Ana Palazon-Cabanes Begoña Palazon-Cabanes Jose Javier Garcia-Medina Aurora Alvarez-Sarrion Monica del-Rio-Vellosillo |
| author_sort | Ana Palazon-Cabanes |
| collection | DOAJ |
| description | Background: This study aims to establish a reference for the superior–inferior hemisphere asymmetry in thickness values for all macular layers for the posterior pole algorithm (PPA) available for the Spectralis SD-OCT device. Methods: We examined 300 eyes of 300 healthy Caucasian volunteers aged 18–84 years using the PPA, composed of a grid of 64 (8 × 8) cells, to analyze the thickness asymmetries of the following automatically segmented macular layers: retinal nerve fiber layer (RNFL); ganglion cell layer (GCL); inner plexiform layer (IPL); inner nuclear layer (INL); outer plexiform layer (OPL); outer nuclear layer (ONL); retinal pigment epithelium (RPE); inner retina; outer retina; complete retina. Mean ± standard deviation and the 2.5th and 97.5th percentiles of the thickness asymmetry values were obtained for all the corresponding cells. Results: All the macular layers had significant superior–inferior thickness asymmetries. GCL, IPL, INL, ONL and RPE showed significantly greater thicknesses in the superior than the inferior hemisphere, whereas RNFL and OPL were thicker in the inferior hemisphere. The largest differences between hemispheres were for RNFL and ONL. Conclusions: This is the first normative database of macular thickness asymmetries for the PPA and should be considered to distinguish normal from pathological values when interpreting superior–inferior macular asymmetries. |
| first_indexed | 2024-03-08T20:38:59Z |
| format | Article |
| id | doaj.art-8ac7cea16daa42138d5f17effe27049f |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-08T20:38:59Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8ac7cea16daa42138d5f17effe27049f2023-12-22T14:17:09ZengMDPI AGJournal of Clinical Medicine2077-03832023-12-011224760910.3390/jcm12247609Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCTAna Palazon-Cabanes0Begoña Palazon-Cabanes1Jose Javier Garcia-Medina2Aurora Alvarez-Sarrion3Monica del-Rio-Vellosillo4Department of Ophthalmology, Hospital Virgen del Castillo, 30510 Murcia, SpainDepartment of Neurology, Hospital de la Vega Lorenzo Guirao, 30530 Murcia, SpainDepartment of Ophthalmology, General University Hospital Morales Meseguer, 30008 Murcia, SpainDepartment of Ophthalmology and Optometry, University of Murcia, 30120 Murcia, SpainDepartment of Anesthesiology, University Hospital Virgen de la Arrixaca, 30120 Murcia, SpainBackground: This study aims to establish a reference for the superior–inferior hemisphere asymmetry in thickness values for all macular layers for the posterior pole algorithm (PPA) available for the Spectralis SD-OCT device. Methods: We examined 300 eyes of 300 healthy Caucasian volunteers aged 18–84 years using the PPA, composed of a grid of 64 (8 × 8) cells, to analyze the thickness asymmetries of the following automatically segmented macular layers: retinal nerve fiber layer (RNFL); ganglion cell layer (GCL); inner plexiform layer (IPL); inner nuclear layer (INL); outer plexiform layer (OPL); outer nuclear layer (ONL); retinal pigment epithelium (RPE); inner retina; outer retina; complete retina. Mean ± standard deviation and the 2.5th and 97.5th percentiles of the thickness asymmetry values were obtained for all the corresponding cells. Results: All the macular layers had significant superior–inferior thickness asymmetries. GCL, IPL, INL, ONL and RPE showed significantly greater thicknesses in the superior than the inferior hemisphere, whereas RNFL and OPL were thicker in the inferior hemisphere. The largest differences between hemispheres were for RNFL and ONL. Conclusions: This is the first normative database of macular thickness asymmetries for the PPA and should be considered to distinguish normal from pathological values when interpreting superior–inferior macular asymmetries.https://www.mdpi.com/2077-0383/12/24/7609normative databaseasymmetryhemispheresthicknessmaculalayer |
| spellingShingle | Ana Palazon-Cabanes Begoña Palazon-Cabanes Jose Javier Garcia-Medina Aurora Alvarez-Sarrion Monica del-Rio-Vellosillo Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT Journal of Clinical Medicine normative database asymmetry hemispheres thickness macula layer |
| title | Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT |
| title_full | Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT |
| title_fullStr | Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT |
| title_full_unstemmed | Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT |
| title_short | Normative Database of the Superior–Inferior Thickness Asymmetry for All Inner and Outer Macular Layers of Adults for the Posterior Pole Algorithm of the Spectralis SD-OCT |
| title_sort | normative database of the superior inferior thickness asymmetry for all inner and outer macular layers of adults for the posterior pole algorithm of the spectralis sd oct |
| topic | normative database asymmetry hemispheres thickness macula layer |
| url | https://www.mdpi.com/2077-0383/12/24/7609 |
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