COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis
As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-05-01
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| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.666067/full |
| _version_ | 1818649768909340672 |
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| author | Mohapradeep Mohan Benjamin Ian Perry Ponnusamy Saravanan Ponnusamy Saravanan Swaran Preet Singh Swaran Preet Singh |
| author_facet | Mohapradeep Mohan Benjamin Ian Perry Ponnusamy Saravanan Ponnusamy Saravanan Swaran Preet Singh Swaran Preet Singh |
| author_sort | Mohapradeep Mohan |
| collection | DOAJ |
| description | As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed. |
| first_indexed | 2024-12-17T01:39:35Z |
| format | Article |
| id | doaj.art-8ac812f763eb417ca28420e4ae430b8a |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-17T01:39:35Z |
| publishDate | 2021-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-8ac812f763eb417ca28420e4ae430b8a2022-12-21T22:08:20ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-05-011210.3389/fpsyt.2021.666067666067COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor PrognosisMohapradeep Mohan0Benjamin Ian Perry1Ponnusamy Saravanan2Ponnusamy Saravanan3Swaran Preet Singh4Swaran Preet Singh5Division of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, United KingdomDepartment of Psychiatry, University of Cambridge, Cambridge, United KingdomPopulations, Evidence and Technologies, Division of Health Sciences, Warwick Medical School, University of Warwick, Coventry, United KingdomAcademic Department of Diabetes, Endocrinology and Metabolism, George Eliot Hospital, Nuneaton, United KingdomDivision of Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, United KingdomCoventry and Warwickshire Partnership Trust, Coventry, United KingdomAs the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.666067/fullschizophreniaCOVID-19severe mental illnessSARS-CoV-2first episode psychosispsychosis |
| spellingShingle | Mohapradeep Mohan Benjamin Ian Perry Ponnusamy Saravanan Ponnusamy Saravanan Swaran Preet Singh Swaran Preet Singh COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis Frontiers in Psychiatry schizophrenia COVID-19 severe mental illness SARS-CoV-2 first episode psychosis psychosis |
| title | COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis |
| title_full | COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis |
| title_fullStr | COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis |
| title_full_unstemmed | COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis |
| title_short | COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis |
| title_sort | covid 19 in people with schizophrenia potential mechanisms linking schizophrenia to poor prognosis |
| topic | schizophrenia COVID-19 severe mental illness SARS-CoV-2 first episode psychosis psychosis |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.666067/full |
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