ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases
Abstract Background The ILD-GAP scoring system is known to be useful in predicting prognosis in patients with interstitial lung disease (ILD). An elevated monocyte count was associated with increased risks of IPF poor prognosis. We examined whether the ILD-GAP scoring system combined with the monocy...
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BMC
2024-01-01
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| Series: | BMC Pulmonary Medicine |
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| Online Access: | https://doi.org/10.1186/s12890-023-02833-6 |
| _version_ | 1797363742163337216 |
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| author | Momo Hirata Yu Hara Hiroaki Fujii Kota Murohashi Yusuke Saigusa Shiqi Zhao Miyu Kobayashi Ryo Nagasawa Yoichi Tagami Ami Izawa Yukiko Otsu Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko |
| author_facet | Momo Hirata Yu Hara Hiroaki Fujii Kota Murohashi Yusuke Saigusa Shiqi Zhao Miyu Kobayashi Ryo Nagasawa Yoichi Tagami Ami Izawa Yukiko Otsu Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko |
| author_sort | Momo Hirata |
| collection | DOAJ |
| description | Abstract Background The ILD-GAP scoring system is known to be useful in predicting prognosis in patients with interstitial lung disease (ILD). An elevated monocyte count was associated with increased risks of IPF poor prognosis. We examined whether the ILD-GAP scoring system combined with the monocyte ratio (ILD-GAPM) is superior to the conventional ILD-GAP model in predicting ILD prognosis. Methods In patients with ILD treated between April 2013 and April 2017, we were retrospectively assessed the relationships between baseline clinical parameters, including age, sex, Charlson Comorbidity Index score (CCIS), ILD diagnosis, blood biomarkers, pulmonary function test results, and disease outcomes. In ILD patients were included idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), collagen vascular disease-related interstitial pneumonia (CVD-IP), chronic hypersensitivity pneumonitis (CHP), and unclassifiable ILD (UC-ILD). We also assessed the ability to predict prognosis was compared between the ILD-GAP and ILD-GAPM models. Results A total of 179 patients (mean age, 73 years) were assessed. All of them were taken pulmonary function test, including percentage predicted diffusion capacity for carbon monoxide. ILD patients included 56 IPF cases, 112 iNSIP and CVD-IP cases, 6 CHP cases and 5 UC-ILD cases. ILD-GAPM provided a greater area under the receiver-operating characteristic curve (0.747) than ILD-GAP (0.710) for predicting 3-year ILD-related events. Furthermore, the log-rank test showed that the Kaplan-Meier curves in ILD-GAPM were significantly different by stage (P = 0.015), but not by stage in ILD-GAP (P = 0.074). Conclusions The ILD-GAPM model may be a more accurate predictor of prognosis for ILD patients than the ILD-GAP model. |
| first_indexed | 2024-03-08T16:24:24Z |
| format | Article |
| id | doaj.art-8ac8e50f41ef409e95e09ec1c5a8f4a9 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-03-08T16:24:24Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
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| series | BMC Pulmonary Medicine |
| spelling | doaj.art-8ac8e50f41ef409e95e09ec1c5a8f4a92024-01-07T12:06:49ZengBMCBMC Pulmonary Medicine1471-24662024-01-0124111110.1186/s12890-023-02833-6ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseasesMomo Hirata0Yu Hara1Hiroaki Fujii2Kota Murohashi3Yusuke Saigusa4Shiqi Zhao5Miyu Kobayashi6Ryo Nagasawa7Yoichi Tagami8Ami Izawa9Yukiko Otsu10Keisuke Watanabe11Nobuyuki Horita12Nobuaki Kobayashi13Takeshi Kaneko14Department of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Biostatistics, Yokohama City University Graduate School of MedicineDepartment of Biostatistics, Yokohama City University Graduate School of MedicineDepartment of Biostatistics, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineDepartment of Pulmonology, Yokohama City University Graduate School of MedicineAbstract Background The ILD-GAP scoring system is known to be useful in predicting prognosis in patients with interstitial lung disease (ILD). An elevated monocyte count was associated with increased risks of IPF poor prognosis. We examined whether the ILD-GAP scoring system combined with the monocyte ratio (ILD-GAPM) is superior to the conventional ILD-GAP model in predicting ILD prognosis. Methods In patients with ILD treated between April 2013 and April 2017, we were retrospectively assessed the relationships between baseline clinical parameters, including age, sex, Charlson Comorbidity Index score (CCIS), ILD diagnosis, blood biomarkers, pulmonary function test results, and disease outcomes. In ILD patients were included idiopathic pulmonary fibrosis (IPF), idiopathic nonspecific interstitial pneumonia (iNSIP), collagen vascular disease-related interstitial pneumonia (CVD-IP), chronic hypersensitivity pneumonitis (CHP), and unclassifiable ILD (UC-ILD). We also assessed the ability to predict prognosis was compared between the ILD-GAP and ILD-GAPM models. Results A total of 179 patients (mean age, 73 years) were assessed. All of them were taken pulmonary function test, including percentage predicted diffusion capacity for carbon monoxide. ILD patients included 56 IPF cases, 112 iNSIP and CVD-IP cases, 6 CHP cases and 5 UC-ILD cases. ILD-GAPM provided a greater area under the receiver-operating characteristic curve (0.747) than ILD-GAP (0.710) for predicting 3-year ILD-related events. Furthermore, the log-rank test showed that the Kaplan-Meier curves in ILD-GAPM were significantly different by stage (P = 0.015), but not by stage in ILD-GAP (P = 0.074). Conclusions The ILD-GAPM model may be a more accurate predictor of prognosis for ILD patients than the ILD-GAP model.https://doi.org/10.1186/s12890-023-02833-6Composite scoring systemDiffusion capacity of lung for carbon monoxideIdiopathic pulmonary fibrosisInterstitial lung diseaseMonocyte ratio |
| spellingShingle | Momo Hirata Yu Hara Hiroaki Fujii Kota Murohashi Yusuke Saigusa Shiqi Zhao Miyu Kobayashi Ryo Nagasawa Yoichi Tagami Ami Izawa Yukiko Otsu Keisuke Watanabe Nobuyuki Horita Nobuaki Kobayashi Takeshi Kaneko ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases BMC Pulmonary Medicine Composite scoring system Diffusion capacity of lung for carbon monoxide Idiopathic pulmonary fibrosis Interstitial lung disease Monocyte ratio |
| title | ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases |
| title_full | ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases |
| title_fullStr | ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases |
| title_full_unstemmed | ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases |
| title_short | ILD-GAP combined with the monocyte ratio could be a better prognostic prediction model than ILD-GAP in patients with interstitial lung diseases |
| title_sort | ild gap combined with the monocyte ratio could be a better prognostic prediction model than ild gap in patients with interstitial lung diseases |
| topic | Composite scoring system Diffusion capacity of lung for carbon monoxide Idiopathic pulmonary fibrosis Interstitial lung disease Monocyte ratio |
| url | https://doi.org/10.1186/s12890-023-02833-6 |
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