High mobility group box-1: a potential therapeutic target for allergic rhinitis
Abstract Allergic rhinitis (AR) is a prevalent chronic inflammatory disease of the nasal mucosa primarily characterized by symptoms, such as nasal itching, sneezing, runny nose, and nasal congestion. It has a high recurrence rate and low cure rate, with a lack of effective drugs for treatment. The c...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | European Journal of Medical Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40001-023-01412-z |
| _version_ | 1797453485869891584 |
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| author | Shuhua Wu Yangyang Yu Zhong Zheng Qi Cheng |
| author_facet | Shuhua Wu Yangyang Yu Zhong Zheng Qi Cheng |
| author_sort | Shuhua Wu |
| collection | DOAJ |
| description | Abstract Allergic rhinitis (AR) is a prevalent chronic inflammatory disease of the nasal mucosa primarily characterized by symptoms, such as nasal itching, sneezing, runny nose, and nasal congestion. It has a high recurrence rate and low cure rate, with a lack of effective drugs for treatment. The current approach to management focuses on symptom control. High mobility group box-1 (HMGB1) is a highly conserved non-histone protein widely present in the nucleus of eukaryotes. It is recognized as a proinflammatory agent, and recent studies have demonstrated its close association with AR. Here, we will elaborate the role and mechanism of HMGB1 in AR, so as to reveal the potential value of HMGB1 in the occurrence and development of AR, and provide a new target for clinical research on the treatment of AR. |
| first_indexed | 2024-03-09T15:23:31Z |
| format | Article |
| id | doaj.art-8ac960969a834cae889a768f9ba5a57e |
| institution | Directory Open Access Journal |
| issn | 2047-783X |
| language | English |
| last_indexed | 2024-03-09T15:23:31Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj.art-8ac960969a834cae889a768f9ba5a57e2023-11-26T12:41:57ZengBMCEuropean Journal of Medical Research2047-783X2023-10-012811910.1186/s40001-023-01412-zHigh mobility group box-1: a potential therapeutic target for allergic rhinitisShuhua Wu0Yangyang Yu1Zhong Zheng2Qi Cheng3Department of Child Otorhinolaryngology, Anhui Provincial Children’s HospitalDepartment of Function Examination Center, Anhui Chest HospitalDepartment of Child Otorhinolaryngology, Anhui Provincial Children’s HospitalDepartment of Child Otorhinolaryngology, Anhui Provincial Children’s HospitalAbstract Allergic rhinitis (AR) is a prevalent chronic inflammatory disease of the nasal mucosa primarily characterized by symptoms, such as nasal itching, sneezing, runny nose, and nasal congestion. It has a high recurrence rate and low cure rate, with a lack of effective drugs for treatment. The current approach to management focuses on symptom control. High mobility group box-1 (HMGB1) is a highly conserved non-histone protein widely present in the nucleus of eukaryotes. It is recognized as a proinflammatory agent, and recent studies have demonstrated its close association with AR. Here, we will elaborate the role and mechanism of HMGB1 in AR, so as to reveal the potential value of HMGB1 in the occurrence and development of AR, and provide a new target for clinical research on the treatment of AR.https://doi.org/10.1186/s40001-023-01412-zAllergic rhinitisHigh mobility group box-1MechanismTarget |
| spellingShingle | Shuhua Wu Yangyang Yu Zhong Zheng Qi Cheng High mobility group box-1: a potential therapeutic target for allergic rhinitis European Journal of Medical Research Allergic rhinitis High mobility group box-1 Mechanism Target |
| title | High mobility group box-1: a potential therapeutic target for allergic rhinitis |
| title_full | High mobility group box-1: a potential therapeutic target for allergic rhinitis |
| title_fullStr | High mobility group box-1: a potential therapeutic target for allergic rhinitis |
| title_full_unstemmed | High mobility group box-1: a potential therapeutic target for allergic rhinitis |
| title_short | High mobility group box-1: a potential therapeutic target for allergic rhinitis |
| title_sort | high mobility group box 1 a potential therapeutic target for allergic rhinitis |
| topic | Allergic rhinitis High mobility group box-1 Mechanism Target |
| url | https://doi.org/10.1186/s40001-023-01412-z |
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