A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial
BackgroundIn recent years frozen-thawed embryo transfer (FET) has played an increasingly important role in ART, but there is limited consensus on the most effective method of endometrial preparation (EP) for FET. Inspired by significantly higher implantation rate and clinical pregnancy rate of the d...
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2021.730059/full |
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| author | Jian-Chun Li Jian-Chun Li Yan-Hong Wang li-Ying Peng Yun Zhou Shi-Bin Chao Shi-Bin Chao |
| author_facet | Jian-Chun Li Jian-Chun Li Yan-Hong Wang li-Ying Peng Yun Zhou Shi-Bin Chao Shi-Bin Chao |
| author_sort | Jian-Chun Li |
| collection | DOAJ |
| description | BackgroundIn recent years frozen-thawed embryo transfer (FET) has played an increasingly important role in ART, but there is limited consensus on the most effective method of endometrial preparation (EP) for FET. Inspired by significantly higher implantation rate and clinical pregnancy rate of the depot GnRH-a protocol, we proposed a novel EP protocol named down-regulation ovulation-induction (DROI) aimed to improve pregnancy outcomes of FET.MethodsThis was a single-center, randomized controlled pilot trial. A total of 307 patients with freeze-all strategy scheduled for first FET were enrolled in the study. A total 261 embryos were transferred in DROI-FET group including 156 patients and 266 embryos were transferred in mNC-FET group including 151 patients. Reproductive outcomes were compared between the two groups.ResultsThe basic characteristics of patients, and the average number, quality and stage of embryos transferred were comparable between the two groups. Our primary outcome, implantation rate(IR) in DROI-FET group, was significantly higher than that of the mNC-FET group (54.41% versus 35.71%, P<0.01). The clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) in DROI-FET group was also higher than that in mNC-FET group (69.87% versus 50.33%, P<0.01; 64.10% versus 42.38%, P<0.01).Conclusion(s)Compared to existing endometrial preparation methods, the DROI protocol might be the more efficient and promising protocol. |
| first_indexed | 2024-12-23T14:02:47Z |
| format | Article |
| id | doaj.art-8aca0fa5f506468ca5f8aca7a53feaef |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T14:02:47Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-8aca0fa5f506468ca5f8aca7a53feaef2022-12-21T17:44:16ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922021-09-011210.3389/fendo.2021.730059730059A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled TrialJian-Chun Li0Jian-Chun Li1Yan-Hong Wang2li-Ying Peng3Yun Zhou4Shi-Bin Chao5Shi-Bin Chao6Department of Clinical Laboratory, The First Affiliated Hospital of NanChang University, NanChang, ChinaART Center, Maternal and Child Health Care Hospital, ShangRao, ChinaART Center, Maternal and Child Health Care Hospital, ShangRao, ChinaDepartment of Reproductive Medicine, Reproductive Hospital Affiliated to Jiangxi University of Traditional Chinese Medicine, Nanchang, ChinaART Center, Maternal and Child Health Care Hospital, ShangRao, ChinaART Center, Maternal and Child Health Care Hospital, ShangRao, ChinaDepartment of Obstetrics and Gynecology, Fuzhou Medical College of NanChang University, Fuzhou, ChinaBackgroundIn recent years frozen-thawed embryo transfer (FET) has played an increasingly important role in ART, but there is limited consensus on the most effective method of endometrial preparation (EP) for FET. Inspired by significantly higher implantation rate and clinical pregnancy rate of the depot GnRH-a protocol, we proposed a novel EP protocol named down-regulation ovulation-induction (DROI) aimed to improve pregnancy outcomes of FET.MethodsThis was a single-center, randomized controlled pilot trial. A total of 307 patients with freeze-all strategy scheduled for first FET were enrolled in the study. A total 261 embryos were transferred in DROI-FET group including 156 patients and 266 embryos were transferred in mNC-FET group including 151 patients. Reproductive outcomes were compared between the two groups.ResultsThe basic characteristics of patients, and the average number, quality and stage of embryos transferred were comparable between the two groups. Our primary outcome, implantation rate(IR) in DROI-FET group, was significantly higher than that of the mNC-FET group (54.41% versus 35.71%, P<0.01). The clinical pregnancy rate (CPR) and ongoing pregnancy rate (OPR) in DROI-FET group was also higher than that in mNC-FET group (69.87% versus 50.33%, P<0.01; 64.10% versus 42.38%, P<0.01).Conclusion(s)Compared to existing endometrial preparation methods, the DROI protocol might be the more efficient and promising protocol.https://www.frontiersin.org/articles/10.3389/fendo.2021.730059/fullfrozen-thawed embryo transferendometrial preparationendometrial receptivityembryo implantationin vitro fertilizationdown regulation ovulation induction |
| spellingShingle | Jian-Chun Li Jian-Chun Li Yan-Hong Wang li-Ying Peng Yun Zhou Shi-Bin Chao Shi-Bin Chao A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial Frontiers in Endocrinology frozen-thawed embryo transfer endometrial preparation endometrial receptivity embryo implantation in vitro fertilization down regulation ovulation induction |
| title | A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial |
| title_full | A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial |
| title_fullStr | A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial |
| title_full_unstemmed | A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial |
| title_short | A Novel Promising Endometrial Preparation Protocol for Frozen-Thawed Embryo Transfer: A Randomized Controlled Trial |
| title_sort | novel promising endometrial preparation protocol for frozen thawed embryo transfer a randomized controlled trial |
| topic | frozen-thawed embryo transfer endometrial preparation endometrial receptivity embryo implantation in vitro fertilization down regulation ovulation induction |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2021.730059/full |
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