Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy
Background: Left ventricular dyssynchrony plays an important role in predicting response to cardiac resynchronization therapy (CRT). Methods: Thirty patients underwent CRT implantation. Assessment of left ventricular (LV) dyssynchrony was done through Gated SPECT LV phase analysis. Results: Thirty p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2016-08-01
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| Series: | Egyptian Journal of Critical Care Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2090730316300226 |
| _version_ | 1797288509552197632 |
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| author | Walid Ahmed Wael Samy Osama Tayeh Noha Behairy Alia Abd el Fattah |
| author_facet | Walid Ahmed Wael Samy Osama Tayeh Noha Behairy Alia Abd el Fattah |
| author_sort | Walid Ahmed |
| collection | DOAJ |
| description | Background: Left ventricular dyssynchrony plays an important role in predicting response to cardiac resynchronization therapy (CRT).
Methods: Thirty patients underwent CRT implantation. Assessment of left ventricular (LV) dyssynchrony was done through Gated SPECT LV phase analysis.
Results: Thirty patients received CRT (mean age 58.7 ± 9.0, 24 males). CRT implantation had a favorable prognosis on cardiac functions (LVEF preimplantation: 26.8 ± 4.7% versus 29.1 ± 6.4% post-implantation; P = 0.002). Reverse LV remodeling (⩾15%) was documented in 19 patients. Temporal changes in LV dyssynchrony parameters were correlated to LV reverse remodeling. Applying ROC curve for LV phase analysis showed that a cutoff value of 152° for histogram bandwidth had a sensitivity of 72.7% and specificity of 63.2% for predicting CRT non-response status. Also, a cutoff value of 54° for histogram standard deviation had a sensitivity of 81.8% and specificity of 63.2%.
Conclusion: Responders of CRT showed improved LV dyssynchrony profiles. Utilizing Gated SPECT LV analysis could provide predictors for CRT non-response. Reverse LV remodeling is associated with temporal improvements in LV dyssynchrony parameters. |
| first_indexed | 2024-03-07T18:50:31Z |
| format | Article |
| id | doaj.art-8acc5d0cbe344b369279b9808b062e36 |
| institution | Directory Open Access Journal |
| issn | 2090-7303 |
| language | English |
| last_indexed | 2024-03-07T18:50:31Z |
| publishDate | 2016-08-01 |
| publisher | Springer |
| record_format | Article |
| series | Egyptian Journal of Critical Care Medicine |
| spelling | doaj.art-8acc5d0cbe344b369279b9808b062e362024-03-02T01:48:20ZengSpringerEgyptian Journal of Critical Care Medicine2090-73032016-08-014210511210.1016/j.ejccm.2016.04.001Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapyWalid Ahmed0Wael Samy1Osama Tayeh2Noha Behairy3Alia Abd el Fattah4Critical Care Medicine Department, Cairo University, 7110 Meerag city, Maadi, Cairo Postal code: 11435, EgyptCritical Care Medicine Department, Cairo University, EgyptCritical Care Medicine Department, Cairo University, EgyptRadiology Department, Cairo University, EgyptCritical Care Medicine Department, Cairo University, EgyptBackground: Left ventricular dyssynchrony plays an important role in predicting response to cardiac resynchronization therapy (CRT). Methods: Thirty patients underwent CRT implantation. Assessment of left ventricular (LV) dyssynchrony was done through Gated SPECT LV phase analysis. Results: Thirty patients received CRT (mean age 58.7 ± 9.0, 24 males). CRT implantation had a favorable prognosis on cardiac functions (LVEF preimplantation: 26.8 ± 4.7% versus 29.1 ± 6.4% post-implantation; P = 0.002). Reverse LV remodeling (⩾15%) was documented in 19 patients. Temporal changes in LV dyssynchrony parameters were correlated to LV reverse remodeling. Applying ROC curve for LV phase analysis showed that a cutoff value of 152° for histogram bandwidth had a sensitivity of 72.7% and specificity of 63.2% for predicting CRT non-response status. Also, a cutoff value of 54° for histogram standard deviation had a sensitivity of 81.8% and specificity of 63.2%. Conclusion: Responders of CRT showed improved LV dyssynchrony profiles. Utilizing Gated SPECT LV analysis could provide predictors for CRT non-response. Reverse LV remodeling is associated with temporal improvements in LV dyssynchrony parameters.http://www.sciencedirect.com/science/article/pii/S2090730316300226Cardiac resynchronization therapyPhase analysis gated SPECTLeft ventricular dyssynchrony |
| spellingShingle | Walid Ahmed Wael Samy Osama Tayeh Noha Behairy Alia Abd el Fattah Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy Egyptian Journal of Critical Care Medicine Cardiac resynchronization therapy Phase analysis gated SPECT Left ventricular dyssynchrony |
| title | Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| title_full | Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| title_fullStr | Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| title_full_unstemmed | Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| title_short | Temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| title_sort | temporal changes of left ventricular synchronization parameters and outcomes of cardiac resynchronization therapy |
| topic | Cardiac resynchronization therapy Phase analysis gated SPECT Left ventricular dyssynchrony |
| url | http://www.sciencedirect.com/science/article/pii/S2090730316300226 |
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