Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children
Introduction: An adipose tissue programming mechanism could be implicated in the extrauterine growth restriction (EUGR) of very preterm infants with morbidity in the cardiometabolic status later in life, as has been reported in intrauterine growth restriction. The aim of this study was to assess whe...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fped.2020.00180/full |
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| author | Maria D. Ordóñez-Díaz Juan L. Pérez-Navero Juan L. Pérez-Navero Katherine Flores-Rojas Josune Olza-Meneses Maria C. Muñoz-Villanueva Concepción M. Aguilera-García Mercedes Gil-Campos |
| author_facet | Maria D. Ordóñez-Díaz Juan L. Pérez-Navero Juan L. Pérez-Navero Katherine Flores-Rojas Josune Olza-Meneses Maria C. Muñoz-Villanueva Concepción M. Aguilera-García Mercedes Gil-Campos |
| author_sort | Maria D. Ordóñez-Díaz |
| collection | DOAJ |
| description | Introduction: An adipose tissue programming mechanism could be implicated in the extrauterine growth restriction (EUGR) of very preterm infants with morbidity in the cardiometabolic status later in life, as has been reported in intrauterine growth restriction. The aim of this study was to assess whether children with a history of prematurity and EUGR, but also with an adequate growth, showed alterations in the metabolic and inflammatory status.Methods: This was a case–control study. A total of 88 prepubertal children with prematurity antecedents were selected: 38 with EUGR and 50 with an adequate growth pattern (PREM group). They were compared with 123 healthy children born at term. Anthropometry, metabolic parameters, blood pressure (BP), C-reactive protein, hepatocyte growth factor (HGF), interleukin-6 (IL-6), IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, tumour necrosis factor-alpha (TNF-α) and plasminogen activator inhibitor type-1 were analysed at the prepubertal age.Results: EUGR children exhibited higher BP levels and a higher prevalence of hypertension (46%) compared with both PREM (10%) and control (2.5%) groups. Moreover, there was a positive relationship between BP levels and values for glucose, insulin and HOMA-IR only in children with a EUGR history. The EUGR group showed higher concentrations of most of the cytokines analysed, markedly higher TNF-α, HGF and MCP-1 levels compared with the other two groups.Conclusion: EUGR status leads to cardiometabolic changes and a low-grade inflammatory status in children with a history of prematurity, and that could be related with cardiovascular risk later in life. |
| first_indexed | 2024-12-20T11:13:06Z |
| format | Article |
| id | doaj.art-8accb308014a41fe92b8c03359fdcbc3 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-12-20T11:13:06Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-8accb308014a41fe92b8c03359fdcbc32022-12-21T19:42:42ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-04-01810.3389/fped.2020.00180517653Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal ChildrenMaria D. Ordóñez-Díaz0Juan L. Pérez-Navero1Juan L. Pérez-Navero2Katherine Flores-Rojas3Josune Olza-Meneses4Maria C. Muñoz-Villanueva5Concepción M. Aguilera-García6Mercedes Gil-Campos7Department of Paediatrics, Maimónides Biomedical Research Institute, Reina Sofía University Hospital, University of Córdoba, Córdoba, SpainDepartment of Paediatrics, Maimónides Biomedical Research Institute, Reina Sofía University Hospital, University of Córdoba, Córdoba, SpainCentre for Biomedical Research on Rare Diseases (CIBERER-ISCIII), Madrid, SpainUnit of Metabolism and Paediatric Research, Maimónides Biomedical Research Institute, Reina Sofia University Hospital, University of Córdoba, Córdoba, SpainLaboratory 123, Department of Biochemistry and Molecular Biology II, Centre of Biomedical Research, Institute of Nutrition and Food Technology, University of Granada, Granada, SpainUnit of Methodological Support to Research, Maimónides Biomedical Research Institute, Córdoba, SpainLaboratory 123, Department of Biochemistry and Molecular Biology II, Centre of Biomedical Research, Institute of Nutrition and Food Technology, University of Granada, Granada, SpainUnit of Metabolism and Paediatric Research, Maimónides Biomedical Research Institute, Reina Sofia University Hospital, University of Córdoba, Córdoba, SpainIntroduction: An adipose tissue programming mechanism could be implicated in the extrauterine growth restriction (EUGR) of very preterm infants with morbidity in the cardiometabolic status later in life, as has been reported in intrauterine growth restriction. The aim of this study was to assess whether children with a history of prematurity and EUGR, but also with an adequate growth, showed alterations in the metabolic and inflammatory status.Methods: This was a case–control study. A total of 88 prepubertal children with prematurity antecedents were selected: 38 with EUGR and 50 with an adequate growth pattern (PREM group). They were compared with 123 healthy children born at term. Anthropometry, metabolic parameters, blood pressure (BP), C-reactive protein, hepatocyte growth factor (HGF), interleukin-6 (IL-6), IL-8, monocyte chemotactic protein type 1 (MCP-1), neural growth factor, tumour necrosis factor-alpha (TNF-α) and plasminogen activator inhibitor type-1 were analysed at the prepubertal age.Results: EUGR children exhibited higher BP levels and a higher prevalence of hypertension (46%) compared with both PREM (10%) and control (2.5%) groups. Moreover, there was a positive relationship between BP levels and values for glucose, insulin and HOMA-IR only in children with a EUGR history. The EUGR group showed higher concentrations of most of the cytokines analysed, markedly higher TNF-α, HGF and MCP-1 levels compared with the other two groups.Conclusion: EUGR status leads to cardiometabolic changes and a low-grade inflammatory status in children with a history of prematurity, and that could be related with cardiovascular risk later in life.https://www.frontiersin.org/article/10.3389/fped.2020.00180/fullprematurityextrauterine growth restrictioninflammationcytokinesmetabolismhypertension |
| spellingShingle | Maria D. Ordóñez-Díaz Juan L. Pérez-Navero Juan L. Pérez-Navero Katherine Flores-Rojas Josune Olza-Meneses Maria C. Muñoz-Villanueva Concepción M. Aguilera-García Mercedes Gil-Campos Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children Frontiers in Pediatrics prematurity extrauterine growth restriction inflammation cytokines metabolism hypertension |
| title | Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children |
| title_full | Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children |
| title_fullStr | Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children |
| title_full_unstemmed | Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children |
| title_short | Prematurity With Extrauterine Growth Restriction Increases the Risk of Higher Levels of Glucose, Low-Grade of Inflammation and Hypertension in Prepubertal Children |
| title_sort | prematurity with extrauterine growth restriction increases the risk of higher levels of glucose low grade of inflammation and hypertension in prepubertal children |
| topic | prematurity extrauterine growth restriction inflammation cytokines metabolism hypertension |
| url | https://www.frontiersin.org/article/10.3389/fped.2020.00180/full |
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