Second primary colorectal cancer after the initial primary colorectal cancer
Abstract Background Initial primary colorectal cancer (IPCRC) has a high risk of developing into second primary colorectal cancer (SPCRC). Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) have different characteristics and are considered to be two different entities. However, the dif...
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| Format: | Article |
| Language: | English |
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BMC
2018-09-01
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| Series: | BMC Cancer |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12885-018-4823-6 |
| _version_ | 1819076496208166912 |
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| author | Lin Yang Zhenchong Xiong Qian Kun Xie Wenzhuo He Shousheng Liu Pengfei Kong Chang Jiang Xiaojun Xia Liangping Xia |
| author_facet | Lin Yang Zhenchong Xiong Qian Kun Xie Wenzhuo He Shousheng Liu Pengfei Kong Chang Jiang Xiaojun Xia Liangping Xia |
| author_sort | Lin Yang |
| collection | DOAJ |
| description | Abstract Background Initial primary colorectal cancer (IPCRC) has a high risk of developing into second primary colorectal cancer (SPCRC). Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) have different characteristics and are considered to be two different entities. However, the different risks for SPCRC in categorized tumor sites and SPCRC subcategorized sites have not been fully elucidated to date. We aimed to compare incidence and survival of IPCRC and SPCRC and characterize the risk factors of SPCRC while also comparing the different SPCRC characteristics. Methods We used the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) data to compute standardized incidence ratios (SIR) in order to estimate risk of SPCRC after IPCRC diagnosis. The most prominent risk factors for SPCRC were measured by multivariate regression analysis and the temporal trend of SPCRC incidence was assessed with Joinpoint regression. Survival of patients with SPCRC and IPCRC was compared by Kaplan-Meier analysis. Results Patients with IPCRC were 1.73 times more likely to develop SPCRC (SIR = 1.73, 95% CI 1.69–1.78). SPCRC incidence declined since the first 8 years of IPCRC diagnosis to baseline. We demonstrated poorer survival with SPCRC compared with IPCRC while second RCC resulted in better survival compared with second LCC. Black ethnicity, age range 70–79, and LCC were associated with the highest risk of developing SPCRC. Conclusion The characteristic differences between second LCC and RCC were relatively narrow. Furthermore, in those with SPCRC, RCC had the best survival outcome. |
| first_indexed | 2024-12-21T18:42:13Z |
| format | Article |
| id | doaj.art-8accd5044e6642cfa6ea9a290943ae5e |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-21T18:42:13Z |
| publishDate | 2018-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-8accd5044e6642cfa6ea9a290943ae5e2022-12-21T18:53:59ZengBMCBMC Cancer1471-24072018-09-011811910.1186/s12885-018-4823-6Second primary colorectal cancer after the initial primary colorectal cancerLin Yang0Zhenchong Xiong1Qian Kun Xie2Wenzhuo He3Shousheng Liu4Pengfei Kong5Chang Jiang6Xiaojun Xia7Liangping Xia8Sun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterSun Yat-sen University Cancer CenterAbstract Background Initial primary colorectal cancer (IPCRC) has a high risk of developing into second primary colorectal cancer (SPCRC). Right-sided colon cancer (RCC) and left-sided colon cancer (LCC) have different characteristics and are considered to be two different entities. However, the different risks for SPCRC in categorized tumor sites and SPCRC subcategorized sites have not been fully elucidated to date. We aimed to compare incidence and survival of IPCRC and SPCRC and characterize the risk factors of SPCRC while also comparing the different SPCRC characteristics. Methods We used the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) data to compute standardized incidence ratios (SIR) in order to estimate risk of SPCRC after IPCRC diagnosis. The most prominent risk factors for SPCRC were measured by multivariate regression analysis and the temporal trend of SPCRC incidence was assessed with Joinpoint regression. Survival of patients with SPCRC and IPCRC was compared by Kaplan-Meier analysis. Results Patients with IPCRC were 1.73 times more likely to develop SPCRC (SIR = 1.73, 95% CI 1.69–1.78). SPCRC incidence declined since the first 8 years of IPCRC diagnosis to baseline. We demonstrated poorer survival with SPCRC compared with IPCRC while second RCC resulted in better survival compared with second LCC. Black ethnicity, age range 70–79, and LCC were associated with the highest risk of developing SPCRC. Conclusion The characteristic differences between second LCC and RCC were relatively narrow. Furthermore, in those with SPCRC, RCC had the best survival outcome.http://link.springer.com/article/10.1186/s12885-018-4823-6Second primary colorectal cancer (SPCRC)Standardized incidence ratio (SIR)Left-sided colon cancer (LCC)Right-sided colon cancer (RCC)Overall survival (OS) |
| spellingShingle | Lin Yang Zhenchong Xiong Qian Kun Xie Wenzhuo He Shousheng Liu Pengfei Kong Chang Jiang Xiaojun Xia Liangping Xia Second primary colorectal cancer after the initial primary colorectal cancer BMC Cancer Second primary colorectal cancer (SPCRC) Standardized incidence ratio (SIR) Left-sided colon cancer (LCC) Right-sided colon cancer (RCC) Overall survival (OS) |
| title | Second primary colorectal cancer after the initial primary colorectal cancer |
| title_full | Second primary colorectal cancer after the initial primary colorectal cancer |
| title_fullStr | Second primary colorectal cancer after the initial primary colorectal cancer |
| title_full_unstemmed | Second primary colorectal cancer after the initial primary colorectal cancer |
| title_short | Second primary colorectal cancer after the initial primary colorectal cancer |
| title_sort | second primary colorectal cancer after the initial primary colorectal cancer |
| topic | Second primary colorectal cancer (SPCRC) Standardized incidence ratio (SIR) Left-sided colon cancer (LCC) Right-sided colon cancer (RCC) Overall survival (OS) |
| url | http://link.springer.com/article/10.1186/s12885-018-4823-6 |
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