Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals

Dopamine-mediated striatal activity and function is enhanced in GlyRα2 knockout animals

Summary: The glycine receptor alpha 2 (GlyRα2) is a ligand-gated ion channel which upon activation induces a chloride conductance. Here, we investigated the role of GlyRα2 in dopamine-stimulated striatal cell activity and behavior. We show that depletion of GlyRα2 enhances dopamine-induced increases...

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Bibliographic Details
Main Authors: Jens Devoght, Joris Comhair, Giovanni Morelli, Jean-Michel Rigo, Rudi D'Hooge, Chadi Touma, Rupert Palme, Ilse Dewachter, Martin vandeVen, Robert J. Harvey, Serge N. Schiffmann, Elisabeth Piccart, Bert Brône
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:iScience
Subjects:
Neuroscience
Behavioral neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223014773

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