Nuclear Phosphoinositides as Key Determinants of Nuclear Functions
Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell. Despite their low concentration, these lipids are critical regulators of various cellular processes, including cell cycle, differentiation, gene trans...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | English |
| Publicado: |
MDPI AG
2023-06-01
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| Colección: | Biomolecules |
| Materias: | |
| Acceso en línea: | https://www.mdpi.com/2218-273X/13/7/1049 |
| _version_ | 1827733692077834240 |
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| author | Magdalena C. Vidalle Bhavwanti Sheth Antonietta Fazio Maria Vittoria Marvi Stefano Leto Foteini-Dionysia Koufi Irene Neri Irene Casalin Giulia Ramazzotti Matilde Y. Follo Stefano Ratti Lucia Manzoli Sonakshi Gehlot Nullin Divecha Roberta Fiume |
| author_facet | Magdalena C. Vidalle Bhavwanti Sheth Antonietta Fazio Maria Vittoria Marvi Stefano Leto Foteini-Dionysia Koufi Irene Neri Irene Casalin Giulia Ramazzotti Matilde Y. Follo Stefano Ratti Lucia Manzoli Sonakshi Gehlot Nullin Divecha Roberta Fiume |
| author_sort | Magdalena C. Vidalle |
| collection | DOAJ |
| description | Polyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell. Despite their low concentration, these lipids are critical regulators of various cellular processes, including cell cycle, differentiation, gene transcription, apoptosis and motility. PPIns are generated by the phosphorylation of the inositol head group of phosphatidylinositol (PtdIns). Different pools of PPIns are found at distinct subcellular compartments, which are regulated by an array of kinases, phosphatases and phospholipases. Six of the seven PPIns species have been found in the nucleus, including the nuclear envelope, the nucleoplasm and the nucleolus. The identification and characterisation of PPIns interactor and effector proteins in the nucleus have led to increasing interest in the role of PPIns in nuclear signalling. However, the regulation and functions of PPIns in the nucleus are complex and are still being elucidated. This review summarises our current understanding of the localisation, biogenesis and physiological functions of the different PPIns species in the nucleus. |
| first_indexed | 2024-03-11T01:15:45Z |
| format | Article |
| id | doaj.art-8acd71ceb0e847d2bbd9c07c1de8f78d |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-11T01:15:45Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8acd71ceb0e847d2bbd9c07c1de8f78d2023-11-18T18:30:40ZengMDPI AGBiomolecules2218-273X2023-06-01137104910.3390/biom13071049Nuclear Phosphoinositides as Key Determinants of Nuclear FunctionsMagdalena C. Vidalle0Bhavwanti Sheth1Antonietta Fazio2Maria Vittoria Marvi3Stefano Leto4Foteini-Dionysia Koufi5Irene Neri6Irene Casalin7Giulia Ramazzotti8Matilde Y. Follo9Stefano Ratti10Lucia Manzoli11Sonakshi Gehlot12Nullin Divecha13Roberta Fiume14Inositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UKInositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UKDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyInositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UKInositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Life Sciences Building 85, Highfield, Southampton SO17 1BJ, UKDepartment of Biomedical Sciences (DIBINEM), University of Bologna, Via Irnerio 48, 40126 Bologna, ItalyPolyphosphoinositides (PPIns) are signalling messengers representing less than five per cent of the total phospholipid concentration within the cell. Despite their low concentration, these lipids are critical regulators of various cellular processes, including cell cycle, differentiation, gene transcription, apoptosis and motility. PPIns are generated by the phosphorylation of the inositol head group of phosphatidylinositol (PtdIns). Different pools of PPIns are found at distinct subcellular compartments, which are regulated by an array of kinases, phosphatases and phospholipases. Six of the seven PPIns species have been found in the nucleus, including the nuclear envelope, the nucleoplasm and the nucleolus. The identification and characterisation of PPIns interactor and effector proteins in the nucleus have led to increasing interest in the role of PPIns in nuclear signalling. However, the regulation and functions of PPIns in the nucleus are complex and are still being elucidated. This review summarises our current understanding of the localisation, biogenesis and physiological functions of the different PPIns species in the nucleus.https://www.mdpi.com/2218-273X/13/7/1049phosphoinositidesPtdIns(4,5)<i>P</i><sub>2</sub>signalling messengerslipidkinasesnucleus |
| spellingShingle | Magdalena C. Vidalle Bhavwanti Sheth Antonietta Fazio Maria Vittoria Marvi Stefano Leto Foteini-Dionysia Koufi Irene Neri Irene Casalin Giulia Ramazzotti Matilde Y. Follo Stefano Ratti Lucia Manzoli Sonakshi Gehlot Nullin Divecha Roberta Fiume Nuclear Phosphoinositides as Key Determinants of Nuclear Functions Biomolecules phosphoinositides PtdIns(4,5)<i>P</i><sub>2</sub> signalling messengers lipid kinases nucleus |
| title | Nuclear Phosphoinositides as Key Determinants of Nuclear Functions |
| title_full | Nuclear Phosphoinositides as Key Determinants of Nuclear Functions |
| title_fullStr | Nuclear Phosphoinositides as Key Determinants of Nuclear Functions |
| title_full_unstemmed | Nuclear Phosphoinositides as Key Determinants of Nuclear Functions |
| title_short | Nuclear Phosphoinositides as Key Determinants of Nuclear Functions |
| title_sort | nuclear phosphoinositides as key determinants of nuclear functions |
| topic | phosphoinositides PtdIns(4,5)<i>P</i><sub>2</sub> signalling messengers lipid kinases nucleus |
| url | https://www.mdpi.com/2218-273X/13/7/1049 |
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