Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins
Background: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | fas |
| Published: |
Isfahan University of Medical Sciences
2011-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/799 |
| Summary: | Background: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxidation. Our goal was to evaluate the effect of vitamin E and iron on blood serum lipids in male rabbits fed high-cholestrol diet.
Method: Thirty white male rabbits were weighed and blood serum samples were taken for analysis of serum lipoproteins. They were randomly divided in to 5 groups each Containing 6 rabbits for 42 days. Group1 was given normal diet. Group 2 fed with high cholesterol (2 %) diet. Group 3 fed with high cholesterol diet with iron (50 mg/kg). Group 4 fed with high cholesterol diet with vitamin E (50 mg/kg). Group 5 fed with high cholesterol diet with iron (50 mg/kg) and vitamin E (50 mg/kg). These groups were again weighed and blood samples were taken for analysis of serum lipoproteins after 42 days.
Results: Significant difference in cholesterol, LDL, HDL, TG, and VLDL were seen before and after the experiment in all 5 groups (P < 0.001).
Conclusion: The significant difference was observed between all groups in relation to the effect of iron and vitamin E on lipid metabolism. While vitamin E has a protective role in atherosclerosis, it seems that iron has a provocation role in serum lipids. |
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| ISSN: | 1027-7595 1735-854X |