Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins
Background: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxi...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2011-03-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/799 |
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| author | Gholamreza Dashti Masoud Poormoghadas Mohammad Hosein Sanei Mohsen Hoseini Seyed Mohammad Ghayoomi |
| author_facet | Gholamreza Dashti Masoud Poormoghadas Mohammad Hosein Sanei Mohsen Hoseini Seyed Mohammad Ghayoomi |
| author_sort | Gholamreza Dashti |
| collection | DOAJ |
| description | Background: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxidation. Our goal was to evaluate the effect of vitamin E and iron on blood serum lipids in male rabbits fed high-cholestrol diet.
Method: Thirty white male rabbits were weighed and blood serum samples were taken for analysis of serum lipoproteins. They were randomly divided in to 5 groups each Containing 6 rabbits for 42 days. Group1 was given normal diet. Group 2 fed with high cholesterol (2 %) diet. Group 3 fed with high cholesterol diet with iron (50 mg/kg). Group 4 fed with high cholesterol diet with vitamin E (50 mg/kg). Group 5 fed with high cholesterol diet with iron (50 mg/kg) and vitamin E (50 mg/kg). These groups were again weighed and blood samples were taken for analysis of serum lipoproteins after 42 days.
Results: Significant difference in cholesterol, LDL, HDL, TG, and VLDL were seen before and after the experiment in all 5 groups (P < 0.001).
Conclusion: The significant difference was observed between all groups in relation to the effect of iron and vitamin E on lipid metabolism. While vitamin E has a protective role in atherosclerosis, it seems that iron has a provocation role in serum lipids. |
| first_indexed | 2024-03-12T07:19:18Z |
| format | Article |
| id | doaj.art-8aceffd611db4aa189fbe03635a51bbd |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T07:19:18Z |
| publishDate | 2011-03-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-8aceffd611db4aa189fbe03635a51bbd2023-09-02T22:36:39ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2011-03-012811812751280534Effect of Ferrous and Vitamin E on Rabbit Serum LipoproteinsGholamreza Dashti0Masoud Poormoghadas1Mohammad Hosein Sanei2Mohsen Hoseini3Seyed Mohammad Ghayoomi4Associate Professor, Department of Anatomical Sciences, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Department of Cardiovascular, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Pathology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Epidemiology & Biostatistics, Isfahan University of Medical Sciences, Isfahan, IranMedical Student, Isfahan University of Medical Sciences, Isfahan, IranBackground: Fatty streaks are the primary lesions to form atherosclerosis. Lipid per oxidation by free- radicals, plays an important role in plaque formation. Vitamin E, as a lipid in soluble vitamin, is an important antioxidant and may prevent or delay the coronary heart disease by limiting LDL oxidation. Our goal was to evaluate the effect of vitamin E and iron on blood serum lipids in male rabbits fed high-cholestrol diet. Method: Thirty white male rabbits were weighed and blood serum samples were taken for analysis of serum lipoproteins. They were randomly divided in to 5 groups each Containing 6 rabbits for 42 days. Group1 was given normal diet. Group 2 fed with high cholesterol (2 %) diet. Group 3 fed with high cholesterol diet with iron (50 mg/kg). Group 4 fed with high cholesterol diet with vitamin E (50 mg/kg). Group 5 fed with high cholesterol diet with iron (50 mg/kg) and vitamin E (50 mg/kg). These groups were again weighed and blood samples were taken for analysis of serum lipoproteins after 42 days. Results: Significant difference in cholesterol, LDL, HDL, TG, and VLDL were seen before and after the experiment in all 5 groups (P < 0.001). Conclusion: The significant difference was observed between all groups in relation to the effect of iron and vitamin E on lipid metabolism. While vitamin E has a protective role in atherosclerosis, it seems that iron has a provocation role in serum lipids.http://jims.mui.ac.ir/index.php/jims/article/view/799CholesterolFerrousVitamin E |
| spellingShingle | Gholamreza Dashti Masoud Poormoghadas Mohammad Hosein Sanei Mohsen Hoseini Seyed Mohammad Ghayoomi Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins مجله دانشکده پزشکی اصفهان Cholesterol Ferrous Vitamin E |
| title | Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins |
| title_full | Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins |
| title_fullStr | Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins |
| title_full_unstemmed | Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins |
| title_short | Effect of Ferrous and Vitamin E on Rabbit Serum Lipoproteins |
| title_sort | effect of ferrous and vitamin e on rabbit serum lipoproteins |
| topic | Cholesterol Ferrous Vitamin E |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/799 |
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