Evaluation of the neurotoxical effect of aluminum on the Wistar rat
Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of alumin...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2010-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003585M.pdf |
| _version_ | 1811315975885160448 |
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| author | Martać L. Podgorac J. Sekulić S. |
| author_facet | Martać L. Podgorac J. Sekulić S. |
| author_sort | Martać L. |
| collection | DOAJ |
| description | Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease. . |
| first_indexed | 2024-04-13T11:40:42Z |
| format | Article |
| id | doaj.art-8ad10eaa3f09434fbb1b80cd379228e3 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 |
| language | English |
| last_indexed | 2024-04-13T11:40:42Z |
| publishDate | 2010-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-8ad10eaa3f09434fbb1b80cd379228e32022-12-22T02:48:19ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46642010-01-0162358558810.2298/ABS1003585MEvaluation of the neurotoxical effect of aluminum on the Wistar ratMartać L.Podgorac J.Sekulić S.Our previous investigations on an animal model of neurotoxicity show that increased power in the delta range is connected with the neurotoxic effect of aluminum exposure. In this study we used several aluminum-treated animals as a reliable model for the evaluation of the neurotoxic effects of aluminum on neurons, and compared it with a control group. We conclude that spectral analysis and the ratio between the delta and theta ranges might be reliable for a qualitative description of the neurotoxic effect of aluminum, and that the t test might be used to evaluate the change in brain activity between the treated and control groups of animals. The animal model under anesthesia was used to describe the state of brain activity with neurotoxicity with suppressed functional connectivity in the brain structure. We also performed fractal analysis to quantitatively describe neurotoxic effect in different pathophysiological states of animals treated with different doses of aluminum. A decrease in the fractal dimension is an indicator of neurodegeneration in the state of stress. This animal model is suitable for evaluation of the neurodegenerative processes in Alzheimer's dementia and Parkinson's disease. .http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003585M.pdfaluminumneurotoxicityWistar rats |
| spellingShingle | Martać L. Podgorac J. Sekulić S. Evaluation of the neurotoxical effect of aluminum on the Wistar rat Archives of Biological Sciences aluminum neurotoxicity Wistar rats |
| title | Evaluation of the neurotoxical effect of aluminum on the Wistar rat |
| title_full | Evaluation of the neurotoxical effect of aluminum on the Wistar rat |
| title_fullStr | Evaluation of the neurotoxical effect of aluminum on the Wistar rat |
| title_full_unstemmed | Evaluation of the neurotoxical effect of aluminum on the Wistar rat |
| title_short | Evaluation of the neurotoxical effect of aluminum on the Wistar rat |
| title_sort | evaluation of the neurotoxical effect of aluminum on the wistar rat |
| topic | aluminum neurotoxicity Wistar rats |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2010/0354-46641003585M.pdf |
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