Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing
Background: Exposure to per- and polyfluoroalkyl substances (PFAS) may disrupt pubertal timing. Higher PFAS plasma concentrations have been associated with later pubertal timing in girls, but cross-sectional findings may be explained by reverse causation. Objectives: To assess prospective associatio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2021-11-01
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| Series: | Environment International |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412021003548 |
| _version_ | 1818915707990048768 |
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| author | Jenny L. Carwile Shravanthi M. Seshasayee Izzuddin M. Aris Sheryl L. Rifas-Shiman Birgit Claus Henn Antonia M. Calafat Sharon K. Sagiv Emily Oken Abby F. Fleisch |
| author_facet | Jenny L. Carwile Shravanthi M. Seshasayee Izzuddin M. Aris Sheryl L. Rifas-Shiman Birgit Claus Henn Antonia M. Calafat Sharon K. Sagiv Emily Oken Abby F. Fleisch |
| author_sort | Jenny L. Carwile |
| collection | DOAJ |
| description | Background: Exposure to per- and polyfluoroalkyl substances (PFAS) may disrupt pubertal timing. Higher PFAS plasma concentrations have been associated with later pubertal timing in girls, but cross-sectional findings may be explained by reverse causation. Objectives: To assess prospective associations between PFAS plasma concentrations in mid-childhood and markers of pubertal timing in male and female adolescents. Methods: We studied 640 children in Project Viva, a Boston-area prospective cohort. We examined associations of plasma concentrations of 6 PFAS measured at mean 7.9 (SD 0.8) years (2007–2010) with markers of pubertal timing. Parents reported a 5-item pubertal development score at early adolescence (mean 13.1 (SD 0.8) years) and reported age at menarche annually. We calculated age at peak height velocity using research and clinical measures of height. We used sex-specific linear and Cox proportional hazards regression to estimate associations of single PFAS with outcomes, and we used Bayesian Kernel Machine Regression (BKMR) to estimate associations of the PFAS mixture with outcomes. Results: Plasma concentrations were highest for perfluorooctane sulfonate (PFOS) [median (IQR) 6.4(5.6) ng/mL], followed by perfluorooctanoate (PFOA) [4.4(3.0) ng/mL]. In early adolescence, girls were further along in puberty than boys [pubertal development score mean (SD) 2.9 (0.7) for girls and 2.2(0.7) for boys; age at peak height velocity mean (SD) 11.2y (1.0) for girls and 13.1y (1.0) for boys]. PFAS was associated with later markers of pubertal timing in girls only. For example, each doubling of PFOA was associated with lower pubertal development score (−0.18 units; 95% CI: −0.30, −0.06) and older age at peak height velocity (0.23 years; 95% CI: 0.06, 0.40)]. We observed similar associations for PFOS, perfluorodecanoate (PFDA), and the PFAS mixture. PFAS plasma concentrations were not associated with age at menarche or markers of pubertal timing in boys. Discussion: Higher PFAS plasma concentrations in mid-childhood were associated with later onset of puberty in girls. |
| first_indexed | 2024-12-20T00:06:34Z |
| format | Article |
| id | doaj.art-8ad1e508c41d49498d1e704287225021 |
| institution | Directory Open Access Journal |
| issn | 0160-4120 |
| language | English |
| last_indexed | 2024-12-20T00:06:34Z |
| publishDate | 2021-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Environment International |
| spelling | doaj.art-8ad1e508c41d49498d1e7042872250212022-12-21T20:00:38ZengElsevierEnvironment International0160-41202021-11-01156106729Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timingJenny L. Carwile0Shravanthi M. Seshasayee1Izzuddin M. Aris2Sheryl L. Rifas-Shiman3Birgit Claus Henn4Antonia M. Calafat5Sharon K. Sagiv6Emily Oken7Abby F. Fleisch8Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA; Corresponding author at: Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, 509 Forest Ave, Portland, ME 04101, USA.Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USADivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USADivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USADepartment of Environmental Health, Boston University School of Public Health, Boston, MA, USADivision of Laboratory Sciences, Centers for Disease Control and Prevention, Atlanta, GA, USADivision of Epidemiology, University of California, Berkeley School of Public Health, Berkeley, CA, USADivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USACenter for Outcomes Research and Evaluation, Maine Medical Center Research Institute, Portland, ME, USA; Pediatric Endocrinology and Diabetes, Maine Medical Center, Portland, ME, USABackground: Exposure to per- and polyfluoroalkyl substances (PFAS) may disrupt pubertal timing. Higher PFAS plasma concentrations have been associated with later pubertal timing in girls, but cross-sectional findings may be explained by reverse causation. Objectives: To assess prospective associations between PFAS plasma concentrations in mid-childhood and markers of pubertal timing in male and female adolescents. Methods: We studied 640 children in Project Viva, a Boston-area prospective cohort. We examined associations of plasma concentrations of 6 PFAS measured at mean 7.9 (SD 0.8) years (2007–2010) with markers of pubertal timing. Parents reported a 5-item pubertal development score at early adolescence (mean 13.1 (SD 0.8) years) and reported age at menarche annually. We calculated age at peak height velocity using research and clinical measures of height. We used sex-specific linear and Cox proportional hazards regression to estimate associations of single PFAS with outcomes, and we used Bayesian Kernel Machine Regression (BKMR) to estimate associations of the PFAS mixture with outcomes. Results: Plasma concentrations were highest for perfluorooctane sulfonate (PFOS) [median (IQR) 6.4(5.6) ng/mL], followed by perfluorooctanoate (PFOA) [4.4(3.0) ng/mL]. In early adolescence, girls were further along in puberty than boys [pubertal development score mean (SD) 2.9 (0.7) for girls and 2.2(0.7) for boys; age at peak height velocity mean (SD) 11.2y (1.0) for girls and 13.1y (1.0) for boys]. PFAS was associated with later markers of pubertal timing in girls only. For example, each doubling of PFOA was associated with lower pubertal development score (−0.18 units; 95% CI: −0.30, −0.06) and older age at peak height velocity (0.23 years; 95% CI: 0.06, 0.40)]. We observed similar associations for PFOS, perfluorodecanoate (PFDA), and the PFAS mixture. PFAS plasma concentrations were not associated with age at menarche or markers of pubertal timing in boys. Discussion: Higher PFAS plasma concentrations in mid-childhood were associated with later onset of puberty in girls.http://www.sciencedirect.com/science/article/pii/S0160412021003548 |
| spellingShingle | Jenny L. Carwile Shravanthi M. Seshasayee Izzuddin M. Aris Sheryl L. Rifas-Shiman Birgit Claus Henn Antonia M. Calafat Sharon K. Sagiv Emily Oken Abby F. Fleisch Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing Environment International |
| title | Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing |
| title_full | Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing |
| title_fullStr | Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing |
| title_full_unstemmed | Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing |
| title_short | Prospective associations of mid-childhood plasma per- and polyfluoroalkyl substances and pubertal timing |
| title_sort | prospective associations of mid childhood plasma per and polyfluoroalkyl substances and pubertal timing |
| url | http://www.sciencedirect.com/science/article/pii/S0160412021003548 |
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