The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis
<b>Objectives:</b> Invasive fungal spondylodiscitis (IFSD) is rare and could be lethal in certain circumstances. The previous literature revealed limited data concerning its outcomes. This study aimed to establish a risk-scoring system to predict the one-year mortality rate of this disea...
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MDPI AG
2024-01-01
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| Series: | Journal of Fungi |
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| Online Access: | https://www.mdpi.com/2309-608X/10/1/61 |
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| author | Chao-Chun Yang Ming-Hsueh Lee Chia-Yen Liu Meng-Hung Lin Yao-Hsu Yang Kuo-Tai Chen Tsung-Yu Huang |
| author_facet | Chao-Chun Yang Ming-Hsueh Lee Chia-Yen Liu Meng-Hung Lin Yao-Hsu Yang Kuo-Tai Chen Tsung-Yu Huang |
| author_sort | Chao-Chun Yang |
| collection | DOAJ |
| description | <b>Objectives:</b> Invasive fungal spondylodiscitis (IFSD) is rare and could be lethal in certain circumstances. The previous literature revealed limited data concerning its outcomes. This study aimed to establish a risk-scoring system to predict the one-year mortality rate of this disease. <b>Methods:</b> A total of 53 patients from a multi-centered database in Taiwan were included in this study. All the clinicopathological and laboratory data were retrospectively analyzed. Variables strongly related to one-year mortality were identified using a multivariate Cox proportional hazards model. A receiver operating characteristic (ROC) curve was used to express the performance of our IFSD scoring model. <b>Results:</b> Five strong predictors were included in the IFSD score: predisposing immunocompromised state, the initial presentation of either radiculopathy or myelopathy, initial laboratory findings of WBC > 12.0 or <0.4 10<sup>3</sup>/µL, hemoglobin < 8 g/dL, and evidence of candidemia. One-year mortality rates for patients with IFSD scores of 0, 1, 2, 3, and 4 were 0%, 16.7%, 56.3%, 72.7%, and 100%, respectively. The area under the curve of the ROC curve was 0.823. <b>Conclusions:</b> We developed a practical scoring model with easily obtained demographic, clinical, and laboratory parameters to predict the probability of one-year mortality in patients with IFSD. However, more large-scale and international validations would be necessary before this scoring model is commonly used. |
| first_indexed | 2024-03-08T10:45:24Z |
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| institution | Directory Open Access Journal |
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| language | English |
| last_indexed | 2024-03-08T10:45:24Z |
| publishDate | 2024-01-01 |
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| record_format | Article |
| series | Journal of Fungi |
| spelling | doaj.art-8ad1f47525204045a1c4dec89b81ffa22024-01-26T17:19:08ZengMDPI AGJournal of Fungi2309-608X2024-01-011016110.3390/jof10010061The IFSD Score—A Practical Prognostic Model for Invasive Fungal SpondylodiscitisChao-Chun Yang0Ming-Hsueh Lee1Chia-Yen Liu2Meng-Hung Lin3Yao-Hsu Yang4Kuo-Tai Chen5Tsung-Yu Huang6Department of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanHealth Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanHealth Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanHealth Information and Epidemiology Laboratory, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDivision of Infectious Diseases, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi 61363, Taiwan<b>Objectives:</b> Invasive fungal spondylodiscitis (IFSD) is rare and could be lethal in certain circumstances. The previous literature revealed limited data concerning its outcomes. This study aimed to establish a risk-scoring system to predict the one-year mortality rate of this disease. <b>Methods:</b> A total of 53 patients from a multi-centered database in Taiwan were included in this study. All the clinicopathological and laboratory data were retrospectively analyzed. Variables strongly related to one-year mortality were identified using a multivariate Cox proportional hazards model. A receiver operating characteristic (ROC) curve was used to express the performance of our IFSD scoring model. <b>Results:</b> Five strong predictors were included in the IFSD score: predisposing immunocompromised state, the initial presentation of either radiculopathy or myelopathy, initial laboratory findings of WBC > 12.0 or <0.4 10<sup>3</sup>/µL, hemoglobin < 8 g/dL, and evidence of candidemia. One-year mortality rates for patients with IFSD scores of 0, 1, 2, 3, and 4 were 0%, 16.7%, 56.3%, 72.7%, and 100%, respectively. The area under the curve of the ROC curve was 0.823. <b>Conclusions:</b> We developed a practical scoring model with easily obtained demographic, clinical, and laboratory parameters to predict the probability of one-year mortality in patients with IFSD. However, more large-scale and international validations would be necessary before this scoring model is commonly used.https://www.mdpi.com/2309-608X/10/1/61invasive fungal infectionfungusCandidaAspergillusspondylodiscitisosteomyelitis |
| spellingShingle | Chao-Chun Yang Ming-Hsueh Lee Chia-Yen Liu Meng-Hung Lin Yao-Hsu Yang Kuo-Tai Chen Tsung-Yu Huang The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis Journal of Fungi invasive fungal infection fungus Candida Aspergillus spondylodiscitis osteomyelitis |
| title | The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis |
| title_full | The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis |
| title_fullStr | The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis |
| title_full_unstemmed | The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis |
| title_short | The IFSD Score—A Practical Prognostic Model for Invasive Fungal Spondylodiscitis |
| title_sort | ifsd score a practical prognostic model for invasive fungal spondylodiscitis |
| topic | invasive fungal infection fungus Candida Aspergillus spondylodiscitis osteomyelitis |
| url | https://www.mdpi.com/2309-608X/10/1/61 |
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