N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4
Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-16306-5 |
| _version_ | 1818851056656842752 |
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| author | Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang |
| author_facet | Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang |
| author_sort | Zihan Li |
| collection | DOAJ |
| description | Dysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cells |
| first_indexed | 2024-12-19T06:58:58Z |
| format | Article |
| id | doaj.art-8ad24c716e8548f1a29032ce576d9050 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T06:58:58Z |
| publishDate | 2020-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8ad24c716e8548f1a29032ce576d90502022-12-21T20:31:28ZengNature PortfolioNature Communications2041-17232020-05-0111111610.1038/s41467-020-16306-5N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4Zihan Li0Yanxi Peng1Jiexin Li2Zhuojia Chen3Feng Chen4Jian Tu5Shuibin Lin6Hongsheng Wang7Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversitySun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer MedicineGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityInstitute of Pharmacy & Pharmacology, University of South ChinaCenter for Translational Medicine, The First Affiliated Hospital, Sun Yat-sen UniversityGuangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen UniversityDysregulation of N6-Methyladenosine (m6A) is associated with cancer progression. Here, authors show that m6A methylation of pyruvate dehydrogenase kinase 4 (PDK4) positively regulates its mRNA stability and translation, and consequently affects glycolysis in cancer cellshttps://doi.org/10.1038/s41467-020-16306-5 |
| spellingShingle | Zihan Li Yanxi Peng Jiexin Li Zhuojia Chen Feng Chen Jian Tu Shuibin Lin Hongsheng Wang N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 Nature Communications |
| title | N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 |
| title_full | N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 |
| title_fullStr | N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 |
| title_full_unstemmed | N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 |
| title_short | N 6 -methyladenosine regulates glycolysis of cancer cells through PDK4 |
| title_sort | n 6 methyladenosine regulates glycolysis of cancer cells through pdk4 |
| url | https://doi.org/10.1038/s41467-020-16306-5 |
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