Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty
Aim: Not only the progressive increase in indications for percutaneous transluminal coronary angioplasty (PTCA) attracts the attention, but also the myocardial damage that may develop after this technique. In this paper, the significance of cardiac markers in detecting myocardial damage followin...
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Format: | Article |
Language: | English |
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Galenos Yayinevi
2010-09-01
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Series: | Haseki Tıp Bülteni |
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Online Access: | http://www.hasekidergisi.com/makale_4575/Perkutan-Transluminal-Koroner-Anjioplasti-Uygulanan-Hastalarda-Ck-mb-Ve-Troponin-I-Duzeyleri-Ozgun-Arastirma |
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author | İnci Y›lmaz Alev Kural Nergis Yamak |
author_facet | İnci Y›lmaz Alev Kural Nergis Yamak |
author_sort | İnci Y›lmaz |
collection | DOAJ |
description | Aim: Not only the progressive increase in indications for
percutaneous transluminal coronary angioplasty (PTCA) attracts
the attention, but also the myocardial damage that may develop
after this technique. In this paper, the significance of cardiac
markers in detecting myocardial damage following PTCA is
discussed.
Methods: 47 randomly selected patients, who have undergone
PTCA procedure for different reasons, had blood analysis of cTnI
and CK-MB levels before and after the procedure between 6 and
12 hours. Chemiluminescent Enzyme Immunoassay method was
applied for cTnI and kinetic immunoinhibition method was
applied for CK-MB.
Results: Significant increase was found in levels of cTnI
(p<0.0001) and CK-MB (p<0.05) after PTCA. A meaningful
increase was detected in levels of cTnI, when compared to
CK-MB in percentage. When patients were subgrupped as SAP,
USAP and post MI angina according to PTCA indications, no
difference was found in the elevation of cTnI and CK-MB levels
(p=0.69, p=0.43).
Conclusion: Subclinical minor complications may occur during
PTCA procedure, such as lateral branch occlusion, distal microembolism,
transient vascular occlusion, etc. This may cause minor
cardiac damage, which may lead to an increase in the levels
of cardiac markers. Cardiac troponins, especially cTnI, are more
sensitive than CK-MB for the diagnosis of cardiac damage.
(The Medical Bulletin of Haseki 2010; 48: 68-71) |
first_indexed | 2024-04-10T12:47:33Z |
format | Article |
id | doaj.art-8ad566e02d154fa682d6c81f7acda371 |
institution | Directory Open Access Journal |
issn | 1302-0072 2147-2688 |
language | English |
last_indexed | 2024-04-10T12:47:33Z |
publishDate | 2010-09-01 |
publisher | Galenos Yayinevi |
record_format | Article |
series | Haseki Tıp Bülteni |
spelling | doaj.art-8ad566e02d154fa682d6c81f7acda3712023-02-15T16:13:58ZengGalenos YayineviHaseki Tıp Bülteni1302-00722147-26882010-09-014836871Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplastyİnci Y›lmaz0Alev Kural1Nergis Yamak2Özel Safa Hastanesi, Biyokimya Klini¤i, ‹stanbul, TürkiyeS.B. Haseki E¤itim ve Araflt›rma Hastanesi, Biyokimya Klini¤i, ‹stanbul, TürkiyeH›fz›ss›hha Enstitüsü, Biyokimya Klini¤i, ‹stanbul, TürkiyeAim: Not only the progressive increase in indications for percutaneous transluminal coronary angioplasty (PTCA) attracts the attention, but also the myocardial damage that may develop after this technique. In this paper, the significance of cardiac markers in detecting myocardial damage following PTCA is discussed. Methods: 47 randomly selected patients, who have undergone PTCA procedure for different reasons, had blood analysis of cTnI and CK-MB levels before and after the procedure between 6 and 12 hours. Chemiluminescent Enzyme Immunoassay method was applied for cTnI and kinetic immunoinhibition method was applied for CK-MB. Results: Significant increase was found in levels of cTnI (p<0.0001) and CK-MB (p<0.05) after PTCA. A meaningful increase was detected in levels of cTnI, when compared to CK-MB in percentage. When patients were subgrupped as SAP, USAP and post MI angina according to PTCA indications, no difference was found in the elevation of cTnI and CK-MB levels (p=0.69, p=0.43). Conclusion: Subclinical minor complications may occur during PTCA procedure, such as lateral branch occlusion, distal microembolism, transient vascular occlusion, etc. This may cause minor cardiac damage, which may lead to an increase in the levels of cardiac markers. Cardiac troponins, especially cTnI, are more sensitive than CK-MB for the diagnosis of cardiac damage. (The Medical Bulletin of Haseki 2010; 48: 68-71)http://www.hasekidergisi.com/makale_4575/Perkutan-Transluminal-Koroner-Anjioplasti-Uygulanan-Hastalarda-Ck-mb-Ve-Troponin-I-Duzeyleri-Ozgun-ArastirmaPercutaneous transluminal coronary angioplastycardiac damagetroponin ICKMB |
spellingShingle | İnci Y›lmaz Alev Kural Nergis Yamak Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty Haseki Tıp Bülteni Percutaneous transluminal coronary angioplasty cardiac damage troponin I CKMB |
title | Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty |
title_full | Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty |
title_fullStr | Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty |
title_full_unstemmed | Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty |
title_short | Levels of CK-MB and Troponin I in Patients who Underwent Percutaneous Transluminal Coronary Angioplasty |
title_sort | levels of ck mb and troponin i in patients who underwent percutaneous transluminal coronary angioplasty |
topic | Percutaneous transluminal coronary angioplasty cardiac damage troponin I CKMB |
url | http://www.hasekidergisi.com/makale_4575/Perkutan-Transluminal-Koroner-Anjioplasti-Uygulanan-Hastalarda-Ck-mb-Ve-Troponin-I-Duzeyleri-Ozgun-Arastirma |
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