Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome
Abstract Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several...
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| Format: | Article |
| Language: | fas |
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Arak Medical University
2017-01-01
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| Series: | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| Subjects: | |
| Online Access: | http://amuj.arakmu.ac.ir/article-1-4579-en.pdf |
| _version_ | 1818525248267485184 |
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| author | Samira Heidarpanah Leila Kohan Seyedeh Sara Hashemi |
| author_facet | Samira Heidarpanah Leila Kohan Seyedeh Sara Hashemi |
| author_sort | Samira Heidarpanah |
| collection | DOAJ |
| description | Abstract
Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of Fas in ovarian apoptosis. The present study is the first investigation to examine the possible association of Fas rs1800682gene polymorphism with PCOS risk in Iranian women.
Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The Fas rs1800682 gene polymorphism genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk.
Results: There was a significant association between A allele and susceptibility to PCOS(OR =1.4, %95CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index(OR=1.6, %95CI=1.02-2.51, p=0.041).
Conclusion: For the first time, this study showed that Fas rs1800682 polymorphism is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS. |
| first_indexed | 2024-12-11T06:06:58Z |
| format | Article |
| id | doaj.art-8ad6d50accb8416a9763195a6d668a73 |
| institution | Directory Open Access Journal |
| issn | 1735-5338 2008-644X |
| language | fas |
| last_indexed | 2024-12-11T06:06:58Z |
| publishDate | 2017-01-01 |
| publisher | Arak Medical University |
| record_format | Article |
| series | Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk |
| spelling | doaj.art-8ad6d50accb8416a9763195a6d668a732022-12-22T01:18:16ZfasArak Medical UniversityMajallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk1735-53382008-644X2017-01-011910916Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary SyndromeSamira Heidarpanah0Leila Kohan1Seyedeh Sara Hashemi2MSc Student of Genetics, Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, IranAssistant Professor, PhD in Cell and Molecular Biology, Department of Biology, Arsanjan Branch, Islamic Azad University, Arsanjan, IranAssistant Professor, PhD in Histology, Burn and Wound Healing Research Center, Shiraz University of Medical Science, Shiraz, IranAbstract Background: Polycystic ovary syndrome(PCOS) is the most common endocrine aberration in women. PCOS is characterized by ovarian hyperandrogenism and anovulation resulted from a disorder of follicular maturation. Apoptosis is a regulatory mechanism for oocyte maturation and survival. Several studies have shown a possible role of Fas in ovarian apoptosis. The present study is the first investigation to examine the possible association of Fas rs1800682gene polymorphism with PCOS risk in Iranian women. Materials and Methods: This case-control study was conducted on 251 patients with PCOS and 213 healthy control women. The Fas rs1800682 gene polymorphism genotypes were analyzed using the Tetra-ARMS-PCR method. Also, logistic regression analysis was used to investigate the association between genotypes and PCOS risk. Results: There was a significant association between A allele and susceptibility to PCOS(OR =1.4, %95CI=1.08-1.83, p=0.011). Moreover, in the recessive genetic model for A allele, the AA genotype increased the risk of PCOS after adjusting age and body mass index(OR=1.6, %95CI=1.02-2.51, p=0.041). Conclusion: For the first time, this study showed that Fas rs1800682 polymorphism is associated with PCOS risk in Iranian women and the A allele may act as a recessive allele for increasing the risk of PCOS.http://amuj.arakmu.ac.ir/article-1-4579-en.pdfFasPolycystic ovary syndromePolymorphism |
| spellingShingle | Samira Heidarpanah Leila Kohan Seyedeh Sara Hashemi Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome Majallah-i dānishgāh-i ̒ulūm-i pizishkī-i Arāk Fas Polycystic ovary syndrome Polymorphism |
| title | Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome |
| title_full | Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome |
| title_fullStr | Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome |
| title_full_unstemmed | Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome |
| title_short | Relationship between Fas rs1800682 Gene Polymorphism and Susceptibility to Polycystic Ovary Syndrome |
| title_sort | relationship between fas rs1800682 gene polymorphism and susceptibility to polycystic ovary syndrome |
| topic | Fas Polycystic ovary syndrome Polymorphism |
| url | http://amuj.arakmu.ac.ir/article-1-4579-en.pdf |
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