A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications
This paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm<sup>2</sup> is implemented through a foundry process calle...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/13/3/425 |
| _version_ | 1797444863067684864 |
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| author | Abbas Panahi Ebrahim Ghafar-Zadeh |
| author_facet | Abbas Panahi Ebrahim Ghafar-Zadeh |
| author_sort | Abbas Panahi |
| collection | DOAJ |
| description | This paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm<sup>2</sup> is implemented through a foundry process called Open-Gate Junction FET (OG-JFET). The proposed OG-JFET sensor with a back gate enables the charge by directly introducing the biological and chemical samples on the top of the device. This paper puts forward the design and implementation of a PDMS microfluidic structure integrated with an OG-JFET chip to direct the samples toward the sensing site. At the same time, the sensor’s gain is controlled with a back gate electrical voltage. Herein, we demonstrate and discuss the functionality and applicability of the proposed sensing platform using a chemical solution with different pH values. Additionally, we introduce a mathematical model to describe the charge sensitivity of the OG-JFET sensor. Based on the results, the maximum value of transconductance gain of the sensor is ~1 mA/V at Vgs = 0, which is decreased to ~0.42 mA/V at Vgs = 1, all in Vds = 5. Furthermore, the variation of the back-gate voltage from 1.0 V to 0.0 V increases the sensitivity from ~40 mV/pH to ~55 mV/pH. As per the experimental and simulation results and discussions in this paper, the proposed hybrid microfluidic OG-JFET sensor is a reliable and high-precision measurement platform for various life science and industrial applications. |
| first_indexed | 2024-03-09T13:17:35Z |
| format | Article |
| id | doaj.art-8ad9ed14d1274123846488704f43d2f5 |
| institution | Directory Open Access Journal |
| issn | 2072-666X |
| language | English |
| last_indexed | 2024-03-09T13:17:35Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj.art-8ad9ed14d1274123846488704f43d2f52023-11-30T21:33:59ZengMDPI AGMicromachines2072-666X2022-03-0113342510.3390/mi13030425A Hybrid Microfluidic Electronic Sensing Platform for Life Science ApplicationsAbbas Panahi0Ebrahim Ghafar-Zadeh1Biologically Inspired Sensors and Actuators (BioSA) Laboratory, Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J1P3, CanadaBiologically Inspired Sensors and Actuators (BioSA) Laboratory, Department of Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON M3J1P3, CanadaThis paper presents a novel hybrid microfluidic electronic sensing platform, featuring an electronic sensor incorporated with a microfluidic structure for life science applications. This sensor with a large sensing area of 0.7 mm<sup>2</sup> is implemented through a foundry process called Open-Gate Junction FET (OG-JFET). The proposed OG-JFET sensor with a back gate enables the charge by directly introducing the biological and chemical samples on the top of the device. This paper puts forward the design and implementation of a PDMS microfluidic structure integrated with an OG-JFET chip to direct the samples toward the sensing site. At the same time, the sensor’s gain is controlled with a back gate electrical voltage. Herein, we demonstrate and discuss the functionality and applicability of the proposed sensing platform using a chemical solution with different pH values. Additionally, we introduce a mathematical model to describe the charge sensitivity of the OG-JFET sensor. Based on the results, the maximum value of transconductance gain of the sensor is ~1 mA/V at Vgs = 0, which is decreased to ~0.42 mA/V at Vgs = 1, all in Vds = 5. Furthermore, the variation of the back-gate voltage from 1.0 V to 0.0 V increases the sensitivity from ~40 mV/pH to ~55 mV/pH. As per the experimental and simulation results and discussions in this paper, the proposed hybrid microfluidic OG-JFET sensor is a reliable and high-precision measurement platform for various life science and industrial applications.https://www.mdpi.com/2072-666X/13/3/425microfluidicsbiosensorISFETfield-effect transistorintegrated biosensorpackaging |
| spellingShingle | Abbas Panahi Ebrahim Ghafar-Zadeh A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications Micromachines microfluidics biosensor ISFET field-effect transistor integrated biosensor packaging |
| title | A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications |
| title_full | A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications |
| title_fullStr | A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications |
| title_full_unstemmed | A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications |
| title_short | A Hybrid Microfluidic Electronic Sensing Platform for Life Science Applications |
| title_sort | hybrid microfluidic electronic sensing platform for life science applications |
| topic | microfluidics biosensor ISFET field-effect transistor integrated biosensor packaging |
| url | https://www.mdpi.com/2072-666X/13/3/425 |
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