Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

Permeability of Metformin across an In Vitro Blood–Brain Barrier Model during Normoxia and Oxygen-Glucose Deprivation Conditions: Role of Organic Cation Transporters (Octs)

Our lab previously established that metformin, a first-line type two diabetes treatment, activates the Nrf2 pathway and improves post-stroke recovery. Metformin’s brain permeability value and potential interaction with blood–brain barrier (BBB) uptake and efflux transporters are currently unknown. M...

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Bibliographic Details
Main Authors: Sejal Sharma, Yong Zhang, Khondker Ayesha Akter, Saeideh Nozohouri, Sabrina Rahman Archie, Dhavalkumar Patel, Heidi Villalba, Thomas Abbruscato
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Pharmaceutics
Subjects:
metformin
ischemic stroke
repurposing
transporters
in vitro
BBB
Online Access:https://www.mdpi.com/1999-4923/15/5/1357

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