Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment
Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage. This modification plays a crucial role in the regulation protein localization, accumulation, secretion, stab...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337478/full |
| _version_ | 1797315992393613312 |
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| author | Yijiao Chen Yongsheng Li Lei Wu |
| author_facet | Yijiao Chen Yongsheng Li Lei Wu |
| author_sort | Yijiao Chen |
| collection | DOAJ |
| description | Protein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage. This modification plays a crucial role in the regulation protein localization, accumulation, secretion, stability, and function. Dysregulation of protein S-palmitoylation can disrupt cellular pathways and contribute to the development of various diseases, particularly cancers. Aberrant S-palmitoylation has been extensively studied and proven to be involved in tumor initiation and growth, metastasis, and apoptosis. In addition, emerging evidence suggests that protein S-palmitoylation may also have a potential role in immune modulation. Therefore, a comprehensive understanding of the regulatory mechanisms of S-palmitoylation in tumor cells and the tumor immune microenvironment is essential to improve our understanding of this process. In this review, we summarize the recent progress of S-palmitoylation in tumors and the tumor immune microenvironment, focusing on the S-palmitoylation modification of various proteins. Furthermore, we propose new ideas for immunotherapeutic strategies through S-palmitoylation intervention. |
| first_indexed | 2024-03-08T03:11:52Z |
| format | Article |
| id | doaj.art-8add056e3b404480bbc353ac7d78167c |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-08T03:11:52Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-8add056e3b404480bbc353ac7d78167c2024-02-13T04:34:56ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-02-011510.3389/fimmu.2024.13374781337478Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironmentYijiao ChenYongsheng LiLei WuProtein S-palmitoylation is a reversible post-translational lipid modification that involves the addition of a 16-carbon palmitoyl group to a protein cysteine residue via a thioester linkage. This modification plays a crucial role in the regulation protein localization, accumulation, secretion, stability, and function. Dysregulation of protein S-palmitoylation can disrupt cellular pathways and contribute to the development of various diseases, particularly cancers. Aberrant S-palmitoylation has been extensively studied and proven to be involved in tumor initiation and growth, metastasis, and apoptosis. In addition, emerging evidence suggests that protein S-palmitoylation may also have a potential role in immune modulation. Therefore, a comprehensive understanding of the regulatory mechanisms of S-palmitoylation in tumor cells and the tumor immune microenvironment is essential to improve our understanding of this process. In this review, we summarize the recent progress of S-palmitoylation in tumors and the tumor immune microenvironment, focusing on the S-palmitoylation modification of various proteins. Furthermore, we propose new ideas for immunotherapeutic strategies through S-palmitoylation intervention.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337478/fullprotein S-palmitoylationlipid modificationtumor cellstumor immune microenvironmentimmunotherapeutic strategies |
| spellingShingle | Yijiao Chen Yongsheng Li Lei Wu Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment Frontiers in Immunology protein S-palmitoylation lipid modification tumor cells tumor immune microenvironment immunotherapeutic strategies |
| title | Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment |
| title_full | Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment |
| title_fullStr | Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment |
| title_full_unstemmed | Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment |
| title_short | Protein S-palmitoylation modification: implications in tumor and tumor immune microenvironment |
| title_sort | protein s palmitoylation modification implications in tumor and tumor immune microenvironment |
| topic | protein S-palmitoylation lipid modification tumor cells tumor immune microenvironment immunotherapeutic strategies |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1337478/full |
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