Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy
Denervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement. We report the ultrasonographic and magnetic resonance imaging (MRI) findings of a patient with diffuse fatty infiltration of c...
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Elsevier
2017-12-01
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| Series: | Radiology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1930043317302200 |
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| author | Kin Hoi Wong, MBBS, FRCR Maria Bernadette Che Ying Chow, MBChB Tun Hing Lui, MBBS, FRCSEd, FHKCOS, FHKAM(Orthopaedic Surgery) Yue Kew Cheong, MBBS, BSc, MRCP, FRCPath, FHKCPath, FHKAM(Pathology) Kwok Fai Tam, MBChB, FRCR, FHKCR, FHKAM(Radiology) |
| author_facet | Kin Hoi Wong, MBBS, FRCR Maria Bernadette Che Ying Chow, MBChB Tun Hing Lui, MBBS, FRCSEd, FHKCOS, FHKAM(Orthopaedic Surgery) Yue Kew Cheong, MBBS, BSc, MRCP, FRCPath, FHKCPath, FHKAM(Pathology) Kwok Fai Tam, MBChB, FRCR, FHKCR, FHKAM(Radiology) |
| author_sort | Kin Hoi Wong, MBBS, FRCR |
| collection | DOAJ |
| description | Denervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement. We report the ultrasonographic and magnetic resonance imaging (MRI) findings of a patient with diffuse fatty infiltration of calf muscles as a result of denervation pseudohypertrophy. The elevated fasting glucose, neurogenic electromyographic changes, and muscle atrophy with adipose tissue infiltration are consistent with diabetic neuropathy as the cause of denervation pseudohypertrophy. Lumbosacral radiculopathy and plexopathy were excluded by MRI. The imaging features reported in the literature are reviewed. The important differential diagnosis of infiltrating lipoma and denervation hypertrophy, as well as other causes of monomelic hypertrophy or swelling, is discussed. This case report demonstrates the importance of MRI, with clinical, biochemical, electrophysiological, and histologic correlation in the diagnosis of denervation pseudohypertrophy. Correct diagnosis of denervation pseudohypertrophy has an important role in guiding further investigations and treatment of the disease and the underlying cause. |
| first_indexed | 2024-12-20T17:21:22Z |
| format | Article |
| id | doaj.art-8add15a7973c4d26be9a91e8f28f1ceb |
| institution | Directory Open Access Journal |
| issn | 1930-0433 |
| language | English |
| last_indexed | 2024-12-20T17:21:22Z |
| publishDate | 2017-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Radiology Case Reports |
| spelling | doaj.art-8add15a7973c4d26be9a91e8f28f1ceb2022-12-21T19:31:48ZengElsevierRadiology Case Reports1930-04332017-12-0112481582010.1016/j.radcr.2017.06.011Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathyKin Hoi Wong, MBBS, FRCR0Maria Bernadette Che Ying Chow, MBChB1Tun Hing Lui, MBBS, FRCSEd, FHKCOS, FHKAM(Orthopaedic Surgery)2Yue Kew Cheong, MBBS, BSc, MRCP, FRCPath, FHKCPath, FHKAM(Pathology)3Kwok Fai Tam, MBChB, FRCR, FHKCR, FHKAM(Radiology)4Department of Radiology, North District Hospital, Sheung Shui, Hong KongDepartment of Pathology, North District Hospital, Sheung Shui, Hong KongDepartment of Orthopaedics and Traumatology, North District Hospital, Sheung Shui, Hong KongDepartment of Pathology, North District Hospital, Sheung Shui, Hong KongDepartment of Radiology, North District Hospital, Sheung Shui, Hong KongDenervation of muscle usually leads to muscle atrophy with fatty replacement but, uncommonly, also results in muscle hypertrophy or pseudohypertrophy with fatty replacement. We report the ultrasonographic and magnetic resonance imaging (MRI) findings of a patient with diffuse fatty infiltration of calf muscles as a result of denervation pseudohypertrophy. The elevated fasting glucose, neurogenic electromyographic changes, and muscle atrophy with adipose tissue infiltration are consistent with diabetic neuropathy as the cause of denervation pseudohypertrophy. Lumbosacral radiculopathy and plexopathy were excluded by MRI. The imaging features reported in the literature are reviewed. The important differential diagnosis of infiltrating lipoma and denervation hypertrophy, as well as other causes of monomelic hypertrophy or swelling, is discussed. This case report demonstrates the importance of MRI, with clinical, biochemical, electrophysiological, and histologic correlation in the diagnosis of denervation pseudohypertrophy. Correct diagnosis of denervation pseudohypertrophy has an important role in guiding further investigations and treatment of the disease and the underlying cause.http://www.sciencedirect.com/science/article/pii/S1930043317302200PseudohypertrophyMuscle denervationDiabetic neuropathyMRI |
| spellingShingle | Kin Hoi Wong, MBBS, FRCR Maria Bernadette Che Ying Chow, MBChB Tun Hing Lui, MBBS, FRCSEd, FHKCOS, FHKAM(Orthopaedic Surgery) Yue Kew Cheong, MBBS, BSc, MRCP, FRCPath, FHKCPath, FHKAM(Pathology) Kwok Fai Tam, MBChB, FRCR, FHKCR, FHKAM(Radiology) Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy Radiology Case Reports Pseudohypertrophy Muscle denervation Diabetic neuropathy MRI |
| title | Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| title_full | Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| title_fullStr | Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| title_full_unstemmed | Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| title_short | Denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| title_sort | denervation pseudohypertrophy of calf muscles associated with diabetic neuropathy |
| topic | Pseudohypertrophy Muscle denervation Diabetic neuropathy MRI |
| url | http://www.sciencedirect.com/science/article/pii/S1930043317302200 |
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