Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate Dehydrogenase

Structural Optimization and Structure–Activity Relationship of 4-Thiazolidinone Derivatives as Novel Inhibitors of Human Dihydroorotate Dehydrogenase

Human dihydroorotate dehydrogenase (<i>h</i>DHODH), one of the attractive targets for the development of immunosuppressive drugs, is also a potential target of anticancer drugs and anti-leukemic drugs. The development of promising <i>h</i>DHODH inhibitors is in high demand. B...

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Bibliographic Details
Main Authors: Fanxun Zeng, Lina Quan, Guantian Yang, Tiantian Qi, Letian Zhang, Shiliang Li, Honglin Li, Lili Zhu, Xiaoyong Xu
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Molecules
Subjects:
<i>h</i>DHODH inhibitors
structural optimization
structure–activity relationship
4-thiazolidinones
Online Access:https://www.mdpi.com/1420-3049/24/15/2780

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