Iron, Aging, and Neurodegeneration
Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the i...
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| Format: | Article |
| Language: | English |
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MDPI AG
2015-11-01
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| Series: | Metals |
| Subjects: | |
| Online Access: | http://www.mdpi.com/2075-4701/5/4/2070 |
| _version_ | 1811243201482194944 |
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| author | Dafina M. Angelova David R. Brown |
| author_facet | Dafina M. Angelova David R. Brown |
| author_sort | Dafina M. Angelova |
| collection | DOAJ |
| description | Iron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to maintaining neuronal viability. During the course of normal aging, the brain changes the way it deals with iron and this can contribute to its susceptibility to disease. Additionally, many of the known neurodegenerative diseases have been shown to be influenced by changes in brain iron. This review examines the role of iron in the brain and neurodegenerative diseases and the potential role of changes in brain iron caused by aging. |
| first_indexed | 2024-04-12T14:03:23Z |
| format | Article |
| id | doaj.art-8addfc6241274b5f99be066f96171620 |
| institution | Directory Open Access Journal |
| issn | 2075-4701 |
| language | English |
| last_indexed | 2024-04-12T14:03:23Z |
| publishDate | 2015-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metals |
| spelling | doaj.art-8addfc6241274b5f99be066f961716202022-12-22T03:30:08ZengMDPI AGMetals2075-47012015-11-01542070209210.3390/met5042070met5042070Iron, Aging, and NeurodegenerationDafina M. Angelova0David R. Brown1Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UKDepartment of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UKIron is a trace element of considerable interest to both chemistry and biology. In a biological context its chemistry is vital to the roles it performs. However, that same chemistry can contribute to a more deleterious role in a variety of diseases. The brain is a very sensitive organ due to the irreplaceable nature of neurons. In this regard regulation of brain iron chemistry is essential to maintaining neuronal viability. During the course of normal aging, the brain changes the way it deals with iron and this can contribute to its susceptibility to disease. Additionally, many of the known neurodegenerative diseases have been shown to be influenced by changes in brain iron. This review examines the role of iron in the brain and neurodegenerative diseases and the potential role of changes in brain iron caused by aging.http://www.mdpi.com/2075-4701/5/4/2070synucleinamyloidprionAlzheimer’s diseaseParkinson’s diseasetransmissible spongiform encephalopathyferrireductasemicroglia |
| spellingShingle | Dafina M. Angelova David R. Brown Iron, Aging, and Neurodegeneration Metals synuclein amyloid prion Alzheimer’s disease Parkinson’s disease transmissible spongiform encephalopathy ferrireductase microglia |
| title | Iron, Aging, and Neurodegeneration |
| title_full | Iron, Aging, and Neurodegeneration |
| title_fullStr | Iron, Aging, and Neurodegeneration |
| title_full_unstemmed | Iron, Aging, and Neurodegeneration |
| title_short | Iron, Aging, and Neurodegeneration |
| title_sort | iron aging and neurodegeneration |
| topic | synuclein amyloid prion Alzheimer’s disease Parkinson’s disease transmissible spongiform encephalopathy ferrireductase microglia |
| url | http://www.mdpi.com/2075-4701/5/4/2070 |
| work_keys_str_mv | AT dafinamangelova ironagingandneurodegeneration AT davidrbrown ironagingandneurodegeneration |