Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases
Adult neurogenesis, restricted to specific regions in the mammalian brain, represents one of the most interesting forms of plasticity in the mature nervous system. Adult-born hippocampal neurons play important roles in certain forms of learning and memory, and altered hippocampal neurogenesis has be...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-08-01
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| Series: | Frontiers in Synaptic Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00004/full |
| _version_ | 1828807468247941120 |
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| author | Krishna eVadodaria Krishna eVadodaria Sebastian eJessberger |
| author_facet | Krishna eVadodaria Krishna eVadodaria Sebastian eJessberger |
| author_sort | Krishna eVadodaria |
| collection | DOAJ |
| description | Adult neurogenesis, restricted to specific regions in the mammalian brain, represents one of the most interesting forms of plasticity in the mature nervous system. Adult-born hippocampal neurons play important roles in certain forms of learning and memory, and altered hippocampal neurogenesis has been associated with a number of neuropsychiatric diseases such as major depression and epilepsy. Newborn neurons go through distinct developmental steps from a dividing neurogenic precursor to a synaptically integrated mature neuron. Previous studies have uncovered several molecular signaling pathways involved in distinct steps of this maturational process. In this context, the small Rho GTPases, Cdc42, Rac1 and RhoA have recently been shown to regulate the morphological and synaptic maturation of adult-born dentate granule cells in vivo. Distinct upstream regulators, including several growth factors that modulate maturation and integration of newborn neurons have been shown to also recruit the small Rho GTPases. Here we review recent findings and highlight the possibility that small Rho GTPases may act as central assimilators, downstream of critical input onto adult-born hippocampal neurons contributing to their maturation and integration into the existing dentate gyrus circuitry. |
| first_indexed | 2024-12-12T08:25:02Z |
| format | Article |
| id | doaj.art-8adf533f0cc241b2bb8551dd8d06c506 |
| institution | Directory Open Access Journal |
| issn | 1663-3563 |
| language | English |
| last_indexed | 2024-12-12T08:25:02Z |
| publishDate | 2013-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Synaptic Neuroscience |
| spelling | doaj.art-8adf533f0cc241b2bb8551dd8d06c5062022-12-22T00:31:16ZengFrontiers Media S.A.Frontiers in Synaptic Neuroscience1663-35632013-08-01510.3389/fnsyn.2013.0000455835Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPasesKrishna eVadodaria0Krishna eVadodaria1Sebastian eJessberger2University of ZurichSalk Institute for Biological StudiesUniversity of ZurichAdult neurogenesis, restricted to specific regions in the mammalian brain, represents one of the most interesting forms of plasticity in the mature nervous system. Adult-born hippocampal neurons play important roles in certain forms of learning and memory, and altered hippocampal neurogenesis has been associated with a number of neuropsychiatric diseases such as major depression and epilepsy. Newborn neurons go through distinct developmental steps from a dividing neurogenic precursor to a synaptically integrated mature neuron. Previous studies have uncovered several molecular signaling pathways involved in distinct steps of this maturational process. In this context, the small Rho GTPases, Cdc42, Rac1 and RhoA have recently been shown to regulate the morphological and synaptic maturation of adult-born dentate granule cells in vivo. Distinct upstream regulators, including several growth factors that modulate maturation and integration of newborn neurons have been shown to also recruit the small Rho GTPases. Here we review recent findings and highlight the possibility that small Rho GTPases may act as central assimilators, downstream of critical input onto adult-born hippocampal neurons contributing to their maturation and integration into the existing dentate gyrus circuitry.http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00004/fullHippocampusNeurogenesisDendritein vivoRac1Cdc42 |
| spellingShingle | Krishna eVadodaria Krishna eVadodaria Sebastian eJessberger Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases Frontiers in Synaptic Neuroscience Hippocampus Neurogenesis Dendrite in vivo Rac1 Cdc42 |
| title | Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases |
| title_full | Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases |
| title_fullStr | Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases |
| title_full_unstemmed | Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases |
| title_short | Maturation and integration of adult born hippocampal neurons: signal convergence onto small Rho GTPases |
| title_sort | maturation and integration of adult born hippocampal neurons signal convergence onto small rho gtpases |
| topic | Hippocampus Neurogenesis Dendrite in vivo Rac1 Cdc42 |
| url | http://journal.frontiersin.org/Journal/10.3389/fnsyn.2013.00004/full |
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