Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function
Background: This study was aimed to evaluate the efficacy of pramipexole combined with ganglioside for PD treatment and pramipexole monotherapy, so as to provide reference for clinical practice. Methods: 61 PD patients selected from June 2019 to December 2020 at our hospital were divided into two gr...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2023-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582303505L.pdf |
| _version_ | 1827801305666551808 |
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| author | Li Xinna Han Peihai Liu Mengjiao Li Xiaowen Xue Shuai |
| author_facet | Li Xinna Han Peihai Liu Mengjiao Li Xiaowen Xue Shuai |
| author_sort | Li Xinna |
| collection | DOAJ |
| description | Background: This study was aimed to evaluate the efficacy of pramipexole combined with ganglioside for PD treatment and pramipexole monotherapy, so as to provide reference for clinical practice. Methods: 61 PD patients selected from June 2019 to December 2020 at our hospital were divided into two groups. The control group (n=31) was given dopasizide oral treatment, and the treatment group (n=30) was given ganglioside combined with pramipexole. The clinical efficacy, adverse reactions, motor function scores, UPDRS scores, PDQ-39 scale scores, TNF-a levels, and related serum factor levels were measured in this study. Results: Compared with control group, the total effective rate was obviously increased. The CRP and TNF-a levels, the speech tone and speed, sitting and walking posture, writing and hands ability scores were reduced, while the BDNF level was increased in treatment group. During the period, compared with the control group, the incidence of adverse reactions in the treatment group was significantly decreased. Conclusion: Ganglioside combined with pramipexole were effective in treating PD. It can effectively reduce the levels of CRP and TNF-a, increase the level of BDNF, improve neurological function, improve motor function, and does not increase the adverse reactions of patients. It is worthy of application. |
| first_indexed | 2024-03-11T20:23:26Z |
| format | Article |
| id | doaj.art-8adfbdace3ff4f50a3d6ae466a55d1e0 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-03-11T20:23:26Z |
| publishDate | 2023-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-8adfbdace3ff4f50a3d6ae466a55d1e02023-10-02T22:17:54ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662023-01-0142350551210.5937/jomb0-425501452-82582303505LEffect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor functionLi Xinna0Han Peihai1Liu Mengjiao2Li Xiaowen3Xue Shuai4The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Department of Pathology, Yantai, ChinaTraditional Chinese Medical Hospital of Huangdao District, Encephalopathy Department, Qingdao, ChinaAffiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer Hospital, Department of Rehabilitation Medicine, Qingdao, ChinaZhangqiu District People's Hospital, Department of Endoscopy Room, Jinan, ChinaShandong University, Cheeloo College of Medicine, Qilu Hospital (Qingdao), Health Care Department, Qingdao, Shandong, ChinaBackground: This study was aimed to evaluate the efficacy of pramipexole combined with ganglioside for PD treatment and pramipexole monotherapy, so as to provide reference for clinical practice. Methods: 61 PD patients selected from June 2019 to December 2020 at our hospital were divided into two groups. The control group (n=31) was given dopasizide oral treatment, and the treatment group (n=30) was given ganglioside combined with pramipexole. The clinical efficacy, adverse reactions, motor function scores, UPDRS scores, PDQ-39 scale scores, TNF-a levels, and related serum factor levels were measured in this study. Results: Compared with control group, the total effective rate was obviously increased. The CRP and TNF-a levels, the speech tone and speed, sitting and walking posture, writing and hands ability scores were reduced, while the BDNF level was increased in treatment group. During the period, compared with the control group, the incidence of adverse reactions in the treatment group was significantly decreased. Conclusion: Ganglioside combined with pramipexole were effective in treating PD. It can effectively reduce the levels of CRP and TNF-a, increase the level of BDNF, improve neurological function, improve motor function, and does not increase the adverse reactions of patients. It is worthy of application.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582303505L.pdfpdgangliosidespramipexolemotor functionupdrs |
| spellingShingle | Li Xinna Han Peihai Liu Mengjiao Li Xiaowen Xue Shuai Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function Journal of Medical Biochemistry pd gangliosides pramipexole motor function updrs |
| title | Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function |
| title_full | Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function |
| title_fullStr | Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function |
| title_full_unstemmed | Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function |
| title_short | Effect of Ganglioside combined with pramexol in the treatment of Parkinson's disease and its effect on motor function |
| title_sort | effect of ganglioside combined with pramexol in the treatment of parkinson s disease and its effect on motor function |
| topic | pd gangliosides pramipexole motor function updrs |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2023/1452-82582303505L.pdf |
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