Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells

BackgroundChronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem cells (MSC). Obesity can impair MSC function by inducing cellular senescence, a growth-arrest program that transitions cells to a pro...

Full description

Bibliographic Details
Main Authors: Sabena M. Conley, LaTonya J. Hickson, Todd A. Kellogg, Travis McKenzie, Julie K. Heimbach, Timucin Taner, Hui Tang, Kyra L. Jordan, Ishran M. Saadiq, John R. Woollard, Busra Isik, Mohsen Afarideh, Tamar Tchkonia, James L. Kirkland, Lilach O. Lerman
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
obesity
mesenchymal stem cells
cellular senescence
adipose tissue
cellular dysfunction
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00197/full

Similar Items

Similar Items