Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?
ABSTRACT Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the cen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2023-02-01
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| Series: | mBio |
| Subjects: | |
| Online Access: | https://journals.asm.org/doi/10.1128/mbio.02920-22 |
| _version_ | 1811163381277655040 |
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| author | Lisa Bauer Debby van Riel |
| author_facet | Lisa Bauer Debby van Riel |
| author_sort | Lisa Bauer |
| collection | DOAJ |
| description | ABSTRACT Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10.1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear. In vivo and in vitro models are useful to study these important questions and may reveal important differences among SARS-CoV-2 variants in their neuroinvasive, neurotropic, and neurovirulent potential. In this commentary we address how this study contributes to the understanding of the neuropathology of SARS-CoV-2 and its variants. |
| first_indexed | 2024-04-10T06:44:09Z |
| format | Article |
| id | doaj.art-8ae2e3e3feb1415ba71b4df088e3873d |
| institution | Directory Open Access Journal |
| issn | 2150-7511 |
| language | English |
| last_indexed | 2024-04-10T06:44:09Z |
| publishDate | 2023-02-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | mBio |
| spelling | doaj.art-8ae2e3e3feb1415ba71b4df088e3873d2023-02-28T14:06:24ZengAmerican Society for MicrobiologymBio2150-75112023-02-0114110.1128/mbio.02920-22Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity?Lisa Bauer0Debby van Riel1Department of Viroscience, Erasmus MC, Rotterdam, The NetherlandsDepartment of Viroscience, Erasmus MC, Rotterdam, The NetherlandsABSTRACT Neurological complications associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are a huge societal problem. Although the neuropathogenicity of SARS-CoV-2 is not yet fully understood, there is evidence that SARS-CoV-2 can invade and infect cells of the central nervous system. Kong et al. (https://doi.org/10.1128/mbio.02308-22) shows that the mechanism of virus entry into astrocytes in brain organoids and primary astrocytes differs from entry into respiratory epithelial cells. However, how SARS-CoV-2 enters susceptible CNS cells and whether there are differences among SARS-CoV-2 variants is still unclear. In vivo and in vitro models are useful to study these important questions and may reveal important differences among SARS-CoV-2 variants in their neuroinvasive, neurotropic, and neurovirulent potential. In this commentary we address how this study contributes to the understanding of the neuropathology of SARS-CoV-2 and its variants.https://journals.asm.org/doi/10.1128/mbio.02920-22neuropathogenesisneuroinvasionneurotropismneurovirulenceCNSastrocytes |
| spellingShingle | Lisa Bauer Debby van Riel Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? mBio neuropathogenesis neuroinvasion neurotropism neurovirulence CNS astrocytes |
| title | Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| title_full | Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| title_fullStr | Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| title_full_unstemmed | Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| title_short | Do SARS-CoV-2 Variants Differ in Their Neuropathogenicity? |
| title_sort | do sars cov 2 variants differ in their neuropathogenicity |
| topic | neuropathogenesis neuroinvasion neurotropism neurovirulence CNS astrocytes |
| url | https://journals.asm.org/doi/10.1128/mbio.02920-22 |
| work_keys_str_mv | AT lisabauer dosarscov2variantsdifferintheirneuropathogenicity AT debbyvanriel dosarscov2variantsdifferintheirneuropathogenicity |