Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT

Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT

Hyperactivity of serine-threonine kinase AKT is one of the most common molecular abnormalities in cancer, where it contributes to poor outcomes by facilitating the growth and survival of malignant cells. Despite its well-documented anti-apoptotic effects, hyperactivity of AKT is also known to be str...

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Bibliographic Details
Main Authors: Mahamat Babagana, Lorin R. Brown, Hannah Z. Slabodkin, Julia V. Kichina, Eugene S. Kandel
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
heat shock
AKT
PTEN
XBP1
HSF1
HSP70
Online Access:https://www.mdpi.com/1422-0067/22/21/11376

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