Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell
A novel coronavirus discovered in 2019 is a new strain of the <i>Coronaviridae</i> family (CoVs) that had not been previously identified in humans. It is known as SARS-CoV-2 for <i>Severe Acute Respiratory Syndrome Coronavirus-2</i>, whilst COVID-19 is the name of the disease...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/7/1818 |
| _version_ | 1827687734806839296 |
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| author | Victor Norris Judit Ovádi |
| author_facet | Victor Norris Judit Ovádi |
| author_sort | Victor Norris |
| collection | DOAJ |
| description | A novel coronavirus discovered in 2019 is a new strain of the <i>Coronaviridae</i> family (CoVs) that had not been previously identified in humans. It is known as SARS-CoV-2 for <i>Severe Acute Respiratory Syndrome Coronavirus-2</i>, whilst COVID-19 is the name of the disease associated with the virus. SARS-CoV-2 emerged over one year ago and still haunts the human community throughout the world, causing both healthcare and socioeconomic problems. SARS-CoV-2 is spreading with many uncertainties about treatment and prevention: the data available are limited and there are few randomized controlled trial data on the efficacy of antiviral or immunomodulatory agents. SARS-CoV-2 and its mutants are considered as unique within the <i>Coronaviridae</i> family insofar as they spread rapidly and can have severe effects on health. Although the scientific world has been succeeding in developing vaccines and medicines to combat COVID-19, the appearance and the spread of new, more aggressive mutants are posing extra problems for treatment. Nevertheless, our understanding of pandemics is increasing significantly due to this outbreak and is leading to the development of many different pharmacological, immunological and other treatments. This Review focuses on a subset of COVID-19 research, primarily the cytoskeleton-related physiological and pathological processes in which coronaviruses such as SARS-CoV-2 are intimately involved. The discovery of the exact mechanisms of the subversion of host cells by SARS-CoV-2 is critical to the validation of specific drug targets and effective treatments. |
| first_indexed | 2024-03-10T09:43:15Z |
| format | Article |
| id | doaj.art-8ae45bb20ea94b0eac815b666df6f3a7 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T09:43:15Z |
| publishDate | 2021-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-8ae45bb20ea94b0eac815b666df6f3a72023-11-22T03:30:37ZengMDPI AGCells2073-44092021-07-01107181810.3390/cells10071818Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a NutshellVictor Norris0Judit Ovádi1Laboratory of Microbiology Signals and Microenvironment, University of Rouen, 76821 Mont Saint Aignan, FranceInstitute of Enzymology, Research Centre for Natural Sciences, ELKH 1117 Budapest, HungaryA novel coronavirus discovered in 2019 is a new strain of the <i>Coronaviridae</i> family (CoVs) that had not been previously identified in humans. It is known as SARS-CoV-2 for <i>Severe Acute Respiratory Syndrome Coronavirus-2</i>, whilst COVID-19 is the name of the disease associated with the virus. SARS-CoV-2 emerged over one year ago and still haunts the human community throughout the world, causing both healthcare and socioeconomic problems. SARS-CoV-2 is spreading with many uncertainties about treatment and prevention: the data available are limited and there are few randomized controlled trial data on the efficacy of antiviral or immunomodulatory agents. SARS-CoV-2 and its mutants are considered as unique within the <i>Coronaviridae</i> family insofar as they spread rapidly and can have severe effects on health. Although the scientific world has been succeeding in developing vaccines and medicines to combat COVID-19, the appearance and the spread of new, more aggressive mutants are posing extra problems for treatment. Nevertheless, our understanding of pandemics is increasing significantly due to this outbreak and is leading to the development of many different pharmacological, immunological and other treatments. This Review focuses on a subset of COVID-19 research, primarily the cytoskeleton-related physiological and pathological processes in which coronaviruses such as SARS-CoV-2 are intimately involved. The discovery of the exact mechanisms of the subversion of host cells by SARS-CoV-2 is critical to the validation of specific drug targets and effective treatments.https://www.mdpi.com/2073-4409/10/7/1818cytoskeletonfilamentsSARS-CoV-2COVID-19drug targets |
| spellingShingle | Victor Norris Judit Ovádi Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell Cells cytoskeleton filaments SARS-CoV-2 COVID-19 drug targets |
| title | Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell |
| title_full | Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell |
| title_fullStr | Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell |
| title_full_unstemmed | Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell |
| title_short | Role of Multifunctional Cytoskeletal Filaments in <i>Coronaviridae</i> Infections: Therapeutic Opportunities for COVID-19 in a Nutshell |
| title_sort | role of multifunctional cytoskeletal filaments in i coronaviridae i infections therapeutic opportunities for covid 19 in a nutshell |
| topic | cytoskeleton filaments SARS-CoV-2 COVID-19 drug targets |
| url | https://www.mdpi.com/2073-4409/10/7/1818 |
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