Prolonged Piezo1 Activation Induces Cardiac Arrhythmia
The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/7/6720 |
| _version_ | 1797607745193508864 |
|---|---|
| author | Laura Rolland Angelo Giovanni Torrente Emmanuel Bourinet Dounia Maskini Aurélien Drouard Philippe Chevalier Chris Jopling Adèle Faucherre |
| author_facet | Laura Rolland Angelo Giovanni Torrente Emmanuel Bourinet Dounia Maskini Aurélien Drouard Philippe Chevalier Chris Jopling Adèle Faucherre |
| author_sort | Laura Rolland |
| collection | DOAJ |
| description | The rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these signals into electrical responses, which can adjust a variety of cardiac parameters such as heart rate and contractility. However, pathological conditions can disrupt this intricate mechanosensory system and manifest as potentially life-threatening cardiac arrhythmias. Mechanosensitive ion channels are thought to be the main proponents of mechanoelectric feedback as they provide a rapid response to mechanical stimulation and can directly affect cardiac electrical activity. Here, we demonstrate that the mechanosensitive ion channel <i>PIEZO1</i> is expressed in zebrafish cardiomyocytes. Furthermore, chemically prolonging <i>PIEZO1</i> activation in zebrafish results in cardiac arrhythmias. indicating that this ion channel plays an important role in mechanoelectric feedback. This also raises the possibility that <i>PIEZO1</i> gain of function mutations could be linked to heritable cardiac arrhythmias in humans. |
| first_indexed | 2024-03-11T05:33:56Z |
| format | Article |
| id | doaj.art-8ae47437aa4544f18b1c6cc377888501 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T05:33:56Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8ae47437aa4544f18b1c6cc3778885012023-11-17T16:55:06ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-04-01247672010.3390/ijms24076720Prolonged Piezo1 Activation Induces Cardiac ArrhythmiaLaura Rolland0Angelo Giovanni Torrente1Emmanuel Bourinet2Dounia Maskini3Aurélien Drouard4Philippe Chevalier5Chris Jopling6Adèle Faucherre7Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceNeuromyogene Institut, Claude Bernard University, Lyon 1, 69008 Villeurbanne, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceInstitute of Functional Genomics, University of Montpellier, CNRS, INSERM, LabEx ICST, 34094 Montpellier, FranceThe rhythmical nature of the cardiovascular system constantly generates dynamic mechanical forces. At the centre of this system is the heart, which must detect these changes and adjust its performance accordingly. Mechanoelectric feedback provides a rapid mechanism for detecting even subtle changes in the mechanical environment and transducing these signals into electrical responses, which can adjust a variety of cardiac parameters such as heart rate and contractility. However, pathological conditions can disrupt this intricate mechanosensory system and manifest as potentially life-threatening cardiac arrhythmias. Mechanosensitive ion channels are thought to be the main proponents of mechanoelectric feedback as they provide a rapid response to mechanical stimulation and can directly affect cardiac electrical activity. Here, we demonstrate that the mechanosensitive ion channel <i>PIEZO1</i> is expressed in zebrafish cardiomyocytes. Furthermore, chemically prolonging <i>PIEZO1</i> activation in zebrafish results in cardiac arrhythmias. indicating that this ion channel plays an important role in mechanoelectric feedback. This also raises the possibility that <i>PIEZO1</i> gain of function mutations could be linked to heritable cardiac arrhythmias in humans.https://www.mdpi.com/1422-0067/24/7/6720cardiac arrhythmiamechanoelectric feedback<i>PIEZO1</i> channel |
| spellingShingle | Laura Rolland Angelo Giovanni Torrente Emmanuel Bourinet Dounia Maskini Aurélien Drouard Philippe Chevalier Chris Jopling Adèle Faucherre Prolonged Piezo1 Activation Induces Cardiac Arrhythmia International Journal of Molecular Sciences cardiac arrhythmia mechanoelectric feedback <i>PIEZO1</i> channel |
| title | Prolonged Piezo1 Activation Induces Cardiac Arrhythmia |
| title_full | Prolonged Piezo1 Activation Induces Cardiac Arrhythmia |
| title_fullStr | Prolonged Piezo1 Activation Induces Cardiac Arrhythmia |
| title_full_unstemmed | Prolonged Piezo1 Activation Induces Cardiac Arrhythmia |
| title_short | Prolonged Piezo1 Activation Induces Cardiac Arrhythmia |
| title_sort | prolonged piezo1 activation induces cardiac arrhythmia |
| topic | cardiac arrhythmia mechanoelectric feedback <i>PIEZO1</i> channel |
| url | https://www.mdpi.com/1422-0067/24/7/6720 |
| work_keys_str_mv | AT laurarolland prolongedpiezo1activationinducescardiacarrhythmia AT angelogiovannitorrente prolongedpiezo1activationinducescardiacarrhythmia AT emmanuelbourinet prolongedpiezo1activationinducescardiacarrhythmia AT douniamaskini prolongedpiezo1activationinducescardiacarrhythmia AT aureliendrouard prolongedpiezo1activationinducescardiacarrhythmia AT philippechevalier prolongedpiezo1activationinducescardiacarrhythmia AT chrisjopling prolongedpiezo1activationinducescardiacarrhythmia AT adelefaucherre prolongedpiezo1activationinducescardiacarrhythmia |