Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort
Chronic obstructive pulmonary disease (COPD) has been regarded as a disease of smokers, but the prevalence of non-smoking COPD patients have been reported to be considerable. We investigated differences in clinical characteristics between smoking and non-smoking COPD patients. We used data from the...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | COPD |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15412555.2022.2053088 |
| _version_ | 1827595141981929472 |
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| author | Joon Young Choi Jin Woo Kim Yee Hyung Kim Kwang Ha Yoo Ki-Suck Jung Jin Hwa Lee Soo-Jung Um Won-Yeon Lee Dongil Park Hyoung Kyu Yoon |
| author_facet | Joon Young Choi Jin Woo Kim Yee Hyung Kim Kwang Ha Yoo Ki-Suck Jung Jin Hwa Lee Soo-Jung Um Won-Yeon Lee Dongil Park Hyoung Kyu Yoon |
| author_sort | Joon Young Choi |
| collection | DOAJ |
| description | Chronic obstructive pulmonary disease (COPD) has been regarded as a disease of smokers, but the prevalence of non-smoking COPD patients have been reported to be considerable. We investigated differences in clinical characteristics between smoking and non-smoking COPD patients. We used data from the Korea COPD Subgroup Study (KOCOSS) database, which is a multicenter cohort that recruits patients from 54 medical centres in Korea. Comprehensive comparisons of smoking and non-smoking COPD patients were performed based on general characteristics, exacerbations, symptom scores, radiological findings, and lung-function tests. Of the 2477 patients included in the study, 8.1% were non-smokers and 91.9% were smokers. Non-smoking COPD patients were more likely to be female and to have a higher body mass index and lower level of education. Non-smoking COPD patients had more comorbidities, including hypertension, osteoporosis, and gastroesophageal reflux disease, and experienced more respiratory and allergic diseases. No significant differences in exacerbation rates, symptom scores, or exercise capacity scores were observed between the two groups. Smoking COPD patients had more emphysematous lung according to the radiological findings, and non-smoking patients had more tuberculosis-destroyed lung and bronchiectasis. Lung-function testing revealed no significant difference in the forced expiratory capacity in 1 sec between the two groups, but smokers had more rapid lung-function decline in the 5 years of follow-up data. We found differences in general characteristics and radiological findings between smoking and non-smoking COPD patients. No significant differences in exacerbation or symptom scores were observed, but decline in lung function was less steep in non-smoking patients. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2053088 . |
| first_indexed | 2024-03-09T02:47:33Z |
| format | Article |
| id | doaj.art-8ae972f816084157be3e0ddcb2ead1e7 |
| institution | Directory Open Access Journal |
| issn | 1541-2555 1541-2563 |
| language | English |
| last_indexed | 2024-03-09T02:47:33Z |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | COPD |
| spelling | doaj.art-8ae972f816084157be3e0ddcb2ead1e72023-12-05T16:09:50ZengTaylor & Francis GroupCOPD1541-25551541-25632022-12-0119117418110.1080/15412555.2022.20530882053088Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS CohortJoon Young Choi0Jin Woo Kim1Yee Hyung Kim2Kwang Ha Yoo3Ki-Suck Jung4Jin Hwa Lee5Soo-Jung Um6Won-Yeon Lee7Dongil Park8Hyoung Kyu Yoon9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Incheon St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDivision of Pulmonology and Critical Care Medicine, Department of Internal Medicine, Uijeongbu St. Mary’s Hospital, College of Medicine, The Catholic University of KoreaDepartment of Pulmonary, Allergy and Critical Care Medicine, Kyung Hee University Hospital at GangdongDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of MedicineDivision of Pulmonary, Allergy and Critical Care Medicine, Hallym University Sacred Heart Hospital, Hallym University Medical SchoolDepartment of Internal Medicine, Ewha Womans University Seoul Hospital, College of Medicine, Ewha Womans UniversityDepartment of Internal Medicine, Pulmonology Division, Dong-A University Hospital, College of Medicine, Dong-A UniversityDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Yonsei University Wonju College of MedicineDepartment of Internal Medicine, Division of Pulmonology, College of Medicine, Chungnam National UniversityDivision of Pulmonology, Critical Care and Sleep Medicine, Department of Internal Medicine, College of Medicine, The Catholic University of KoreaChronic obstructive pulmonary disease (COPD) has been regarded as a disease of smokers, but the prevalence of non-smoking COPD patients have been reported to be considerable. We investigated differences in clinical characteristics between smoking and non-smoking COPD patients. We used data from the Korea COPD Subgroup Study (KOCOSS) database, which is a multicenter cohort that recruits patients from 54 medical centres in Korea. Comprehensive comparisons of smoking and non-smoking COPD patients were performed based on general characteristics, exacerbations, symptom scores, radiological findings, and lung-function tests. Of the 2477 patients included in the study, 8.1% were non-smokers and 91.9% were smokers. Non-smoking COPD patients were more likely to be female and to have a higher body mass index and lower level of education. Non-smoking COPD patients had more comorbidities, including hypertension, osteoporosis, and gastroesophageal reflux disease, and experienced more respiratory and allergic diseases. No significant differences in exacerbation rates, symptom scores, or exercise capacity scores were observed between the two groups. Smoking COPD patients had more emphysematous lung according to the radiological findings, and non-smoking patients had more tuberculosis-destroyed lung and bronchiectasis. Lung-function testing revealed no significant difference in the forced expiratory capacity in 1 sec between the two groups, but smokers had more rapid lung-function decline in the 5 years of follow-up data. We found differences in general characteristics and radiological findings between smoking and non-smoking COPD patients. No significant differences in exacerbation or symptom scores were observed, but decline in lung function was less steep in non-smoking patients. Supplemental data for this article is available online at https://doi.org/10.1080/15412555.2022.2053088 .http://dx.doi.org/10.1080/15412555.2022.2053088copdnon-smoking copdkocoss databasecohort studysouth korea |
| spellingShingle | Joon Young Choi Jin Woo Kim Yee Hyung Kim Kwang Ha Yoo Ki-Suck Jung Jin Hwa Lee Soo-Jung Um Won-Yeon Lee Dongil Park Hyoung Kyu Yoon Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort COPD copd non-smoking copd kocoss database cohort study south korea |
| title | Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort |
| title_full | Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort |
| title_fullStr | Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort |
| title_full_unstemmed | Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort |
| title_short | Clinical Characteristics of Non-Smoking Chronic Obstructive Pulmonary Disease Patients: Findings from the KOCOSS Cohort |
| title_sort | clinical characteristics of non smoking chronic obstructive pulmonary disease patients findings from the kocoss cohort |
| topic | copd non-smoking copd kocoss database cohort study south korea |
| url | http://dx.doi.org/10.1080/15412555.2022.2053088 |
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