Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder
Abstract Background The neural correlate of cognitive deficits in bipolar disorder (BD) is an issue that warrants further investigation. However, relatively few studies have examined the intrinsic functional connectivity (FC) underlying cognitive deficits involving sustained attention and executive...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-05083-2 |
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| author | Yan-Kun Wu Yun-Ai Su Lin-Lin Zhu Ji-Tao Li Qian Li You-Ran Dai Jing-Yu Lin Ke Li Tian-Mei Si |
| author_facet | Yan-Kun Wu Yun-Ai Su Lin-Lin Zhu Ji-Tao Li Qian Li You-Ran Dai Jing-Yu Lin Ke Li Tian-Mei Si |
| author_sort | Yan-Kun Wu |
| collection | DOAJ |
| description | Abstract Background The neural correlate of cognitive deficits in bipolar disorder (BD) is an issue that warrants further investigation. However, relatively few studies have examined the intrinsic functional connectivity (FC) underlying cognitive deficits involving sustained attention and executive function at both the region and network levels, as well as the different relationships between connectivity patterns and cognitive performance, in BD patients and healthy controls (HCs). Methods Patients with BD (n = 59) and HCs (n = 52) underwent structural and resting-state functional magnetic resonance imaging and completed the Wisconsin Card Sorting Test (WCST), the continuous performance test and a clinical assessment. A seed-based approach was used to evaluate the intrinsic FC alterations in three core neurocognitive networks (the default mode network [DMN], the central executive network [CEN] and the salience network [SN]). Finally, we examined the relationship between FC and cognitive performance by using linear regression analyses. Results Decreased FC was observed within the DMN, in the DMN-SN and DMN-CEN and increased FC was observed in the SN-CEN in BD. The alteration direction of regional FC was consistent with that of FC at the brain network level. Decreased FC between the left posterior cingulate cortex and right anterior cingulate cortex was associated with longer WCST completion time in BD patients (but not in HCs). Conclusions These findings emphasize the dominant role of the DMN in the psychopathology of BD and provide evidence that cognitive deficits in BD may be associated with aberrant FC between the anterior and posterior DMN. |
| first_indexed | 2024-03-09T15:00:05Z |
| format | Article |
| id | doaj.art-8aeaf2c451cc4e6bba79c8ffb1422c2f |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-09T15:00:05Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-8aeaf2c451cc4e6bba79c8ffb1422c2f2023-11-26T13:56:30ZengBMCBMC Psychiatry1471-244X2023-08-0123111310.1186/s12888-023-05083-2Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorderYan-Kun Wu0Yun-Ai Su1Lin-Lin Zhu2Ji-Tao Li3Qian Li4You-Ran Dai5Jing-Yu Lin6Ke Li7Tian-Mei Si8Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)PLA Strategic Support Force Characteristic Medical CenterPeking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital)Abstract Background The neural correlate of cognitive deficits in bipolar disorder (BD) is an issue that warrants further investigation. However, relatively few studies have examined the intrinsic functional connectivity (FC) underlying cognitive deficits involving sustained attention and executive function at both the region and network levels, as well as the different relationships between connectivity patterns and cognitive performance, in BD patients and healthy controls (HCs). Methods Patients with BD (n = 59) and HCs (n = 52) underwent structural and resting-state functional magnetic resonance imaging and completed the Wisconsin Card Sorting Test (WCST), the continuous performance test and a clinical assessment. A seed-based approach was used to evaluate the intrinsic FC alterations in three core neurocognitive networks (the default mode network [DMN], the central executive network [CEN] and the salience network [SN]). Finally, we examined the relationship between FC and cognitive performance by using linear regression analyses. Results Decreased FC was observed within the DMN, in the DMN-SN and DMN-CEN and increased FC was observed in the SN-CEN in BD. The alteration direction of regional FC was consistent with that of FC at the brain network level. Decreased FC between the left posterior cingulate cortex and right anterior cingulate cortex was associated with longer WCST completion time in BD patients (but not in HCs). Conclusions These findings emphasize the dominant role of the DMN in the psychopathology of BD and provide evidence that cognitive deficits in BD may be associated with aberrant FC between the anterior and posterior DMN.https://doi.org/10.1186/s12888-023-05083-2Magnetic resonance imagingBipolar disorderDefault mode networkExecutive functionAttention |
| spellingShingle | Yan-Kun Wu Yun-Ai Su Lin-Lin Zhu Ji-Tao Li Qian Li You-Ran Dai Jing-Yu Lin Ke Li Tian-Mei Si Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder BMC Psychiatry Magnetic resonance imaging Bipolar disorder Default mode network Executive function Attention |
| title | Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| title_full | Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| title_fullStr | Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| title_full_unstemmed | Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| title_short | Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| title_sort | intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder |
| topic | Magnetic resonance imaging Bipolar disorder Default mode network Executive function Attention |
| url | https://doi.org/10.1186/s12888-023-05083-2 |
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