Susac Syndrome Following COVID-19 Vaccination: A Case Report
Due to the COVID-19 pandemic, numerous vaccines have been developed for the disease. However, with large-scale vaccination has come the gradual emergence of immunological phenomena caused by these new vaccines. Herein, we report a 48-year-old female with a sudden onset of inferior visual field defec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/3/363 |
| _version_ | 1797441226514890752 |
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| author | Po-Jui Chen Yi-Sheng Chang Chen-Chee Lim Yu-Kuei Lee |
| author_facet | Po-Jui Chen Yi-Sheng Chang Chen-Chee Lim Yu-Kuei Lee |
| author_sort | Po-Jui Chen |
| collection | DOAJ |
| description | Due to the COVID-19 pandemic, numerous vaccines have been developed for the disease. However, with large-scale vaccination has come the gradual emergence of immunological phenomena caused by these new vaccines. Herein, we report a 48-year-old female with a sudden onset of inferior visual field defects in the left eye following her first dose of the ChAdOx1 vaccine. Dilated fundus examination combined with optical coherence tomography and fluorescein angiography confirmed the diagnosis of branch retinal artery occlusion. Within 4 weeks following vaccination, symptoms associated with hearing impairment developed, and magnetic resonance imaging revealed leptomeningeal enhancement. The diagnosis of Susac syndrome (SS) was confirmed. The development of SS may be caused by endotheliopathy resulting from the molecular mimicry of the ChAdOx1 vaccine. Clinicians should be aware of the symptoms of SS, which may develop after COVID-19 vaccination. Further experimental surveillance and case–control studies are required to confirm this relationship. |
| first_indexed | 2024-03-09T12:19:58Z |
| format | Article |
| id | doaj.art-8aeaf812e99447d9b298cd34968730b5 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T12:19:58Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-8aeaf812e99447d9b298cd34968730b52023-11-30T22:41:55ZengMDPI AGVaccines2076-393X2022-02-0110336310.3390/vaccines10030363Susac Syndrome Following COVID-19 Vaccination: A Case ReportPo-Jui Chen0Yi-Sheng Chang1Chen-Chee Lim2Yu-Kuei Lee3Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDepartment of Ophthalmology, Tainan Hospital, Ministry of Health and Welfare, Tainan 700, TaiwanDepartment of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 704, TaiwanDue to the COVID-19 pandemic, numerous vaccines have been developed for the disease. However, with large-scale vaccination has come the gradual emergence of immunological phenomena caused by these new vaccines. Herein, we report a 48-year-old female with a sudden onset of inferior visual field defects in the left eye following her first dose of the ChAdOx1 vaccine. Dilated fundus examination combined with optical coherence tomography and fluorescein angiography confirmed the diagnosis of branch retinal artery occlusion. Within 4 weeks following vaccination, symptoms associated with hearing impairment developed, and magnetic resonance imaging revealed leptomeningeal enhancement. The diagnosis of Susac syndrome (SS) was confirmed. The development of SS may be caused by endotheliopathy resulting from the molecular mimicry of the ChAdOx1 vaccine. Clinicians should be aware of the symptoms of SS, which may develop after COVID-19 vaccination. Further experimental surveillance and case–control studies are required to confirm this relationship.https://www.mdpi.com/2076-393X/10/3/363Susac syndromeCOVID-19 vaccineadenoviral vector vaccinecase report |
| spellingShingle | Po-Jui Chen Yi-Sheng Chang Chen-Chee Lim Yu-Kuei Lee Susac Syndrome Following COVID-19 Vaccination: A Case Report Vaccines Susac syndrome COVID-19 vaccine adenoviral vector vaccine case report |
| title | Susac Syndrome Following COVID-19 Vaccination: A Case Report |
| title_full | Susac Syndrome Following COVID-19 Vaccination: A Case Report |
| title_fullStr | Susac Syndrome Following COVID-19 Vaccination: A Case Report |
| title_full_unstemmed | Susac Syndrome Following COVID-19 Vaccination: A Case Report |
| title_short | Susac Syndrome Following COVID-19 Vaccination: A Case Report |
| title_sort | susac syndrome following covid 19 vaccination a case report |
| topic | Susac syndrome COVID-19 vaccine adenoviral vector vaccine case report |
| url | https://www.mdpi.com/2076-393X/10/3/363 |
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