Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin
Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, there has been no available pharmacological treat...
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| Format: | Article |
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MDPI AG
2022-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/8/2564 |
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| author | Ramón Rodrigo Catalina Retamal Denisse Schupper Diego Vergara-Hernández Sarmistha Saha Elisabetta Profumo Brigitta Buttari Luciano Saso |
| author_facet | Ramón Rodrigo Catalina Retamal Denisse Schupper Diego Vergara-Hernández Sarmistha Saha Elisabetta Profumo Brigitta Buttari Luciano Saso |
| author_sort | Ramón Rodrigo |
| collection | DOAJ |
| description | Ischemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, there has been no available pharmacological treatment until now. Oxidative stress contributes to the underlying production mechanism, exerting the most marked injury during the early onset of reperfusion. So far, antioxidants have been shown to protect the AMI patients undergoing PCI to mitigate these detrimental effects; however, no clinical trials to date have shown any significant infarct size reduction. Therefore, it is worthwhile to consider multitarget antioxidant therapies targeting multifactorial AMI. Indeed, this clinical setting involves injurious effects derived from oxygen deprivation, intracellular pH changes and increased concentration of cytosolic Ca<sup>2+</sup> and reactive oxygen species, among others. Thus, we will review a brief overview of the pathological cascades involved in ischemia-reperfusion injury and the potential therapeutic effects based on preclinical studies involving a combination of antioxidants, with particular reference to resveratrol and quercetin, which could contribute to cardioprotection against ischemia-reperfusion injury in myocardial tissue. We will also highlight the upcoming perspectives of these antioxidants for designing future studies. |
| first_indexed | 2024-03-09T10:31:15Z |
| format | Article |
| id | doaj.art-8aebb5c9d7d24b0ab3b5ee2a4ea97339 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T10:31:15Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8aebb5c9d7d24b0ab3b5ee2a4ea973392023-12-01T21:16:22ZengMDPI AGMolecules1420-30492022-04-01278256410.3390/molecules27082564Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and QuercetinRamón Rodrigo0Catalina Retamal1Denisse Schupper2Diego Vergara-Hernández3Sarmistha Saha4Elisabetta Profumo5Brigitta Buttari6Luciano Saso7Molecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago P.O. Box 70111, ChileMolecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago P.O. Box 70111, ChileMolecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago P.O. Box 70111, ChileMolecular and Clinical Pharmacology Program, Faculty of Medicine, Institute of Biomedical Sciences, University of Chile, Santiago P.O. Box 70111, ChileIndian Institute of Technology Gandhinagar, Palaj, Gandhinagar 382055, Gujarat, IndiaDepartment of Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, 00161 Rome, ItalyDepartment of Cardiovascular, Endocrine-Metabolic Diseases, and Aging, Italian National Institute of Health, 00161 Rome, ItalyDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, 00161 Rome, ItalyIschemia-reperfusion myocardial damage is a paradoxical tissue injury occurring during percutaneous coronary intervention (PCI) in acute myocardial infarction (AMI) patients. Although this damage could account for up to 50% of the final infarct size, there has been no available pharmacological treatment until now. Oxidative stress contributes to the underlying production mechanism, exerting the most marked injury during the early onset of reperfusion. So far, antioxidants have been shown to protect the AMI patients undergoing PCI to mitigate these detrimental effects; however, no clinical trials to date have shown any significant infarct size reduction. Therefore, it is worthwhile to consider multitarget antioxidant therapies targeting multifactorial AMI. Indeed, this clinical setting involves injurious effects derived from oxygen deprivation, intracellular pH changes and increased concentration of cytosolic Ca<sup>2+</sup> and reactive oxygen species, among others. Thus, we will review a brief overview of the pathological cascades involved in ischemia-reperfusion injury and the potential therapeutic effects based on preclinical studies involving a combination of antioxidants, with particular reference to resveratrol and quercetin, which could contribute to cardioprotection against ischemia-reperfusion injury in myocardial tissue. We will also highlight the upcoming perspectives of these antioxidants for designing future studies.https://www.mdpi.com/1420-3049/27/8/2564oxidative stressreperfusion injuryantioxidantsresveratrolquercetincardioprotection |
| spellingShingle | Ramón Rodrigo Catalina Retamal Denisse Schupper Diego Vergara-Hernández Sarmistha Saha Elisabetta Profumo Brigitta Buttari Luciano Saso Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin Molecules oxidative stress reperfusion injury antioxidants resveratrol quercetin cardioprotection |
| title | Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin |
| title_full | Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin |
| title_fullStr | Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin |
| title_full_unstemmed | Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin |
| title_short | Antioxidant Cardioprotection against Reperfusion Injury: Potential Therapeutic Roles of Resveratrol and Quercetin |
| title_sort | antioxidant cardioprotection against reperfusion injury potential therapeutic roles of resveratrol and quercetin |
| topic | oxidative stress reperfusion injury antioxidants resveratrol quercetin cardioprotection |
| url | https://www.mdpi.com/1420-3049/27/8/2564 |
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